摘要
目的探索纳洛酮联合无创呼吸机在慢性阻塞性肺疾病急性加重期(AECOPD)并呼吸衰竭患者中的临床疗效。方法选取我院收治的AECOPD合并呼吸衰竭患者103例,随机分为观察组和对照组,分别为50例与53例,对照组给予常规治疗及无创呼吸机辅助通气,观察组在对照组的基础上给予盐酸纳洛酮治疗。观察治疗前后疗效、血气指标的变化,再插管率,病死率,住院时间,血清胱抑素(CysC)变化。结果 AECOPD合并呼吸衰竭应用纳洛酮联合双水平无创正压通气,其总有效率、住院时间优于单纯应用无创呼吸机组,但是再插管率与病死率两组差异没有统计学意义。观察组血气指标及CysC水平改善要优于对照组。结论纳洛酮联合无创呼吸机能有效改善AECOPD并呼吸衰竭患者的症状和体征,缩短住院时间,改善血气分析指标及血清Cysc水平,但并不能改善再插管率和病死率。
Objective To explore the clinical effect of naloxone combined with noninvasive positive pressure ventilation in the treatment of acute exacerbation of chronic obstructive pulmonary disease（AECOPD） complicated with respiratory failure. Methods A total of 103 AECOPD participants complicated with respiratory failure, hospitalized in our hospital were included and then randomly divided into the treatment group （ n =50） and control group （ n =53）. All patients were treated with noninvasive positive pressure ventilation and conventional therapy, while patients in the treatment group received additional treatment with naloxone. Results The total effective rate, length of hospital stay, blood gas and serum level of cystatin C （CysC） in the treatment group were all better than those in the control group （P 〈0.05）, but the reintubation rate and mortality showed no statistical significance between two groups （P 0.05）. Conclusion Naloxone combined with noninvasive positive pressure ventilation can not only effectively improve the signs and symptoms as well as the blood gas, but also reduce the serum level of CysC and shorten the length of hospital stay. However, it does not improve the reintubation rates and mortality.
出处
《临床荟萃》
CAS
2015年第3期293-296,共4页
Clinical Focus
关键词
肺疾病
慢性阻塞性
呼吸功能不全
纳洛酮
气道管理
pulmonary disease, chronic obstructive
respiratory insufficiency
naloxone
airway management
