摘要
肝癌术后患者常因肝脏组织代偿和恢复功能受限,术后急性肝衰竭的发病率及病死率较高.骨髓间充质干细胞可以在肝脏微环境下直接分化为新的肝细胞,通过分泌营养因子促进组织修复、参与免疫调节、抗纤维化和抑制肝星状细胞和肝原细胞的活性等,对肝损伤及肝功能不全具有较好的疗效.然而骨髓间充质干细胞同时具有致瘤性和促进肿瘤生长的作用.利用骨髓间充质干细胞预防和治疗肝癌术后肝衰竭的发生是否安全可靠,这是目前研究的热点问题.本文就骨髓间充质干细胞对于原发性肝癌影响作用的研究进展进行综述,以期为干细胞的临床应用提供理论基础.
Liver cancer is the common malignant tumors of threat to human health and life,which makes the high mortality rate of patients with liver cancer.Mesenchymal stem cells can differentiate in the liver microenvironment of new liver cells,and promote tissue repair by secreting neurotrophic factors involved in immune regulation,anti-fibrosis and inhibition of hepatic stellate cells and liver progenitor cells activity and other characteristics of treatment of liver cancer has broad prospects.In this paper,mesenchymal stem cell research progress of the influence of primary liver cancer were reviewed.
出处
《国际外科学杂志》
2015年第1期64-66,共3页
International Journal of Surgery
基金
国家自然科学基金（No.81473504）
高等学校博士学科点专项科研基金（No.20122105110009）
关键词
肝肿瘤
间质干细胞
研究进展
Liver neoplasms
Mesenchymal stem cells
Progress
