摘要
目的观察不同年龄及性别慢性乙肝住院患者的焦虑、抑郁发生情况,探讨其可能的影响因素及干预措施。方法采用定式临床会诊量表(DSM-Ⅳ轴Ⅰ障碍)对160例慢性乙肝住院患者的精神状态进行测评及问卷调查,根据不同干预措施分成3组:药物干预组、药物配合心理干预组和空白对照组,比较不同干预措施的临床疗效。结果抑郁发病率16%,焦虑发病率14%。女性抑郁、焦虑的发病率较男性高,差异有统计学意义(P=0.020,P=0.029),年龄40岁以下的慢性乙肝患者抑郁和焦虑的发病率均高于40岁以上者,差异有统计学意义(P=0.045,P=0.021)。不熟悉乙肝相关知识的患者抑郁和焦虑的发病率明显高于熟悉者(P=0.001,P=0.006)。人际关系不佳的患者抑郁和焦虑发病率显著高于有良好人际关系的患者(P=0.002,P=0.047)。药物干预(P=0.001,P=0.040)和药物联合心理干预(P=0.027,P=0.005)均可有效缓解乙肝患者的抑郁和焦虑,且后者疗效显著高于前者(χ2=23.41,P=0.001;χ2=4.26,P=0.033)。结论慢性乙肝患者中抑郁和焦虑的发病情况与年龄、性别、对乙肝知识的了解以及人际关系有关。药物干预与药物联合心理干预对缓解抑郁和焦虑均有明显效果,且药物联合心理干预的效果更为显著。
Objective To investigate the occurrence and interventions of anxiety and depression among chronic viral hepatitis B in-patients with different ages and genders.Methods The psychosis of 160 chronic viral hepatitis B in-patients were evaluated by Structured Clinical Interview for the DSM-Ⅳ（AxisⅠ Disorders）,and patients were divided into drug intervention group,drug and psychological intervention group and control group.The clinical curative effects of three groups were compared.Results The incidence rates of patients with female,under the age of 40,not familiar with hepatitis B related knowledge and poor interpersonal relationships were higher than patients with male,more than 40 years old,familiar with hepatitis B related knowledge and good interpersonal relationships.Drug intervention,drug and psychological intervention could effectively relieve the depression and anxiety of chronic viral hepatitis B in-patients.Conclusion The depression and anxiety of chronic viral hepatitis B patients are related to age,gender,relationship condition and knowledge about the disease.Both drug and drug combined with psychotherapy interventions have significant effect on relieving the depression and anxiety,especially in the latter.
出处
《中国实用神经疾病杂志》
2015年第4期31-34,共4页
Chinese Journal of Practical Nervous Diseases
关键词
乙型肝炎
年龄
性别
焦虑
抑郁
Chronic virus hepatitis B
Age
Gender
Anxiety
Depression
