摘要
钙敏感受体(CaSR)是G蛋白偶联受体(GPCRs)C家族的成员,其在神经系统、心血管系统、胃肠道、肾脏及骨组织中有广泛的分布,当与激动剂及变构调节剂结合后,激活下游相关信号通路,对于机体钙稳态的维持、细胞的增殖分化、免疫及多种内分泌激素的释放具有重要调节作用。目前的研究报告主要来自于牛、人、鼠等,对家畜和其他动物的研究还较少,对机体各项生命活动的调控作用也不明确。为此,本文从CaSR的发现、结构、介导的信号活动及生理作用等方面作一综述,以期为研究CaSR调节动物生理活动的机制及发挥的生理功能奠定理论基础。
Calcium-sensing receptor （ CaSR） is a member of the G protein-coupled receptors （ GPCRs） C fam-ily, and wildly expressed in nervous system, cardiovascular system, gastrointestinal tract, kidney and bone tis-sue. After combined with its agonists and allosteric modulators, the downstream signaling pathways are activa-ted, which play very important roles in the regulation of calcium homeostasis, cell proliferation and differentia-tion, immune function and endocrine hormone releasing. However, recent researches mostly focus on cattle, human and mice. The studies on livestock and other animals are limited, and undergoing mechanisms of physi-ological functions of CaSR mediation are not clear enough. Therefore, this paper summarized the discovery, the structure, mediated signaling events and physiological effects of the CaSR, in order to lay a theoretical foundation for further study on livestock and other animals.
出处
《动物营养学报》
CAS
CSCD
北大核心
2015年第3期703-714,共12页
CHINESE JOURNAL OF ANIMAL NUTRITION
基金
国家973项目(2013CB127301)
关键词
钙敏感受体
G蛋白偶联受体
信号传导通路
生理功能
calcium-sensing receptor
G protein-coupled receptor
signaling pathways
physiological functions
