摘要
目的分析卡培他滨维持化疗治疗晚期和术后复发转移胃癌的效果及安全性。方法选择2008—2011年在上饶市上饶县人民医院经6个周期全身化疗后缓解的晚期及术后复发转移的胃癌患者80例,将患者按治疗方法不同分为观察组与对照组,各40例。两组患者经全身化疗后予以常规对症支持治疗,观察组在常规治疗基础上口服卡培他滨治疗。观察两组患者的生存情况及毒副作用情况。结果观察组患者生存时间长于对照组,差异有统计学意义(P<0.05);观察组患者1、2年生存率高于对照组(P<0.0);观察组患者毒副作用发生率为45.0%,对照组为40.0%,两组患者毒副作用发生率比较,差异无统计学意义(P>0.05)。结论卡培他滨维持化疗治疗晚期和术后复发转移胃癌的效果显著,可延长患者生存时间,改善其生活质量,且不增加毒副作用,安全性高。
Objective To analyze the effectiveness and security of capecitabine maintenance chemotherapy on ad-vanced gastric cancer or postoperative recurrence and metastasis. Methods A total of 80 patients with advanced gastric cancer or postoperative recurrence and metastasis were selected in the People＆#39;s Hospital of Shangrao County from 2008 to 2011,all of them received 6 cycles of systemic chemotherapy,and they were divided into observation group and control group according to the different treatment methods,each of 40 cases. Both groups given conventional symptomatic supportive treatment,and observa-tion group given extra capecitabine. The survival situation,toxic and side effect were compared between the two groups. Results The survival time of observation group was longer than that of control group（ P 〈 0. 05）;the 1 — year survival rate and 2 — year survival rate of observation group were higher than those of control group（P 〈0. 05）;the incidence of toxic and side effect of observation group was 45. 0%,that of control group was 40. 0%,the difference was not significantly different（ P 〉0. 05）. Conclusion Capecitabine maintenance chemotherapy has a notable curative effect in the treatment of advanced gastric cancer or postoperative recurrence and metastasis,can improve the quality of life,without increasing the incidence of toxic and side effect,is safe.
出处
《临床合理用药杂志》
2015年第6期13-14,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
胃肿瘤
维持化疗
卡培他滨
治疗结果
安全性
Stomach neoplasms
Maintenance chemotherapy
Capecitabine
Treatment outcome
Safety
