摘要
目的探讨针对急性肺部细菌性感染患者使用盐酸左氧氟沙星序贯治疗的临床效果及不良反应。方法选取2012年9月-2013年12月医院急性肺部细菌性感染患者160例,对其送检标本进行病原菌检测,菌种鉴定采用法国生物梅里埃公司的VITEK-60全自动细菌分析仪,药物敏感试验采用方法是K-B纸片扩散法;按数学随机方法分为普通组和治疗组,各80例,普通组使用盐酸左氧氟沙星注射液治疗,治疗组使用盐酸左氧氟沙星注射液及胶囊序贯方案治疗,对比两组治疗效果及不良反应。结果 160例感染患者培养分离出186株病原菌,革兰阴性菌133株占71.51%,革兰阳性菌53株占28.49%,肺炎克雷伯菌、铜绿假单胞菌、肺炎链球菌、不动杆菌属、金黄色葡萄球菌为主要菌种;治疗有效率普通组患者为92.50%、治疗组患者为92.50%,对比差异无统计学意义;不良反应发生率普通组患者为3.75%、治疗组患者为2.50%,两组不良反应发生率对比差异无统计学意义。结论针对急性肺部细菌性感染患者使用盐酸左氧氟沙星注射液及胶囊序贯治疗的临床效果与仅使用盐酸左氧氟沙星注射液治疗的效果相近,序贯治疗经济性较好且安全性更高,值得临床推广应用。
OBJECTIVE To observe the clinical effect of levofloxacin hydrochloride on sequential treatment of the patients with acute pulmonary bacterial infections and analyze the adverse reactions .METHODS A total of 160 pa-tients with acute pulmonary bacterial infections who were treated in the hospital from Sep 2012 to Dec 2013 were enrolled in the study ,then the submitted specimens were detected for pathogens ,the bacterial identification was carried out by using VITEK-60 automatic bacterial analyzer of bioMerieux ,France ,the drug susceptibility testing was performed with the use of K-B disk diffusion method .The participants were randomly divided into the com-mon group and the treatment group ,with 80 cases in each ; the common group was treated with levofloxacin hydrochloride injection ,while the treatment group was given levofloxacin hydrochloride injection and capsule for sequential therapy ;the curative effect and adverse reactions were observed and compared between the two groups . RESULTS Totally 186 strains of pathogens have been isolated from the 160 patients with infections ,including 133 （71 .51% ） strains of gram-negative bacteria and 53 （28 .49% ） strains of gram-positive bacteria ;the K lebsiella pneumoniae ,Pseudomonas aeruginosa ,Streptococcus pneumoniae ,Acinetobacter sp p ,and Staphylococcus aureus were the predominant species of pathogens .The effective rate of treatment was 92 .50% in the common group , 92 .50% in the treatment group , there was no significant difference . The incidence of adverse reactions was 3 .75% in the common group ,2 .50% in the treatment group ,there was no significant difference between the two groups .CONCLUSION The clinical effect of the levofloxacin hydrochloride injection and capsule sequential therapy is similar to the effect of the single use of levofloxacin hydrochloride injection on the treatment of the patients with acute pulmonary bacterial infections ,and the sequential therapy is more economical and safe and is worthy to be promoted in the hospital .
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2015年第6期1288-1290,共3页
Chinese Journal of Nosocomiology
基金
高等学校博士学科科研基金资助项目(200802260009)
关键词
急性肺部细菌性感染
盐酸左氧氟沙星
临床效果
Acute pulmonary bacterial infection
Levofloxacin hydrochloride
Clinical effect
