摘要
目的观察微创穴位埋线联合西药治疗稳定期中重度慢性阻塞性肺疾病(COPD)的临床疗效。方法将200例中重度COPD稳定期患者随机分为治疗组与对照组,每组100例。对照组予西医常规治疗,治疗组在对照组治疗措施基础上加用微创穴位埋线治疗。两组疗程均为1年,观察AECOPD次数、重度急性发作次数、SGQR评分(临床症状、活动能力、疾病影响等)、焦虑HAMA及抑郁HAMD评分、6 min步行距离、肺功能(FEV1、FEV1/FVC)及安全性指标变化情况。结果 1最终完成试验病例185例,治疗组脱落7例,对照组脱落8例。2组间治疗后比较,AECOPD次数、重度急性发作次数、SGQR评分(临床症状、活动能力、疾病影响评分及总分)、HAMA及HAMD评分、6MWT差异有统计学意义(P<0.05)。3组间治疗后比较,肺功能(FEV1、FEV1/FVC)水平差异无统计学意义(P>0.05)。4两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论微创穴位埋线联合西药治疗稳定期中重度慢性阻塞性肺疾病,可显著减少AECOPD(尤其重度急性发作)次数,改善患者临床症状、活动耐力及焦虑抑郁心理。
Objective To observe the clinical efficacy of minimally invasive thread-embedding at acupoints combined with western medicine in treating moderate to severe chronic obstructive pulmonary disease（ COPD） in stable phase. Methods Two hundred patients with moderate to severe COPD in stable phase were randomly divided into the treatment group and control group,with 100 cases in each group. The control group was treated with conventional western medicine,and the treatment group was treated with minimally invasive thread-embedding at acupoints additionally,with the course of one year. The times of acute exacerbation of COPD（ AECOPD）,severe exacerbations,SGRQ score,Hamilton Anxiety Scale（ HAMA）,Hamilton Depression Scale（ HAMD）,6 minutes walking distance（ 6MWD）,and lung function（ FEV1,FEV1/ FVC）,as well as the safety indexes were observed. Results ① One hundred and eighty-five patients were followed up for 1-year,7 patients were lost in the treatment group,while 8 patients were lost in the control group. ②After treatment,there were significant differences in AECOPD,number of severe exacerbations,SGRQ score,HAMA,HAMD,and 6MWD between the two groups（ P〈0. 05）. ③ After treatment,no significant difference was found in the levels of FEV1 and FEV1/ FVC between the two groups（ P〉0. 05）. ④ No significant difference was found in adverse reaction rate between the two groups（ P〉0. 05）. Conclusion Combined minimally invasive thread-embedding at acupoints and western medicine is effective to reduce the number of AECOPD,and improve the clinical symptoms,activity endurance,and relieve depression and anxiety in patients with moderate to severe COPD in stable phase.
出处
《上海中医药杂志》
2015年第3期38-42,共5页
Shanghai Journal of Traditional Chinese Medicine
基金
上海市卫生局科研基金项目(2010216)
关键词
慢性阻塞性肺疾病
稳定期
中重度
微创穴位埋线
急性发作
6分钟步行试验
chronic obstructive pulmonary disease（COPD）
stable phase
moderate or severe
minimally invasive thread-embedding at acupoint
acute exacerbation
6 minutes walking distance（6MWD）
