摘要
目的探讨参麦注射液联合布地奈德治疗急性酒精中毒合并吸入性肺炎的疗效,为临床治疗提供相应依据。方法 100例符合纳入标准的急性酒精中毒合并吸入性肺炎的患者随机分为两组,每组各50例。对照组给予布地奈德治疗,观察组在对照组的基础上联合使用参麦注射液治疗。记录并比较两组患者酒精中毒症状疗效、肺炎相关症状消失时间、肝功能及炎性因子变化情况。结果观察组清醒时间和血压恢复时间明显短于对照组,清醒后出现头晕、头痛和电解质紊乱的患者例数明显少于对照组,差异均有统计学意义(均P<0.05)。观察组肺炎相关症状咳嗽、气喘、哮鸣音及湿啰音消失时间明显短于对照组,差异均有统计学意义(均P<0.05)。与对照组相比,观察组肝功能指标ALT、AST和GGT改善更明显,炎性因子TNF-α、IL-6和CRP水平下降更明显,差异均有统计学意义(均P<0.05)。结论参麦注射液联合布地奈德治疗急性酒精中毒合并吸入性肺炎疗效可靠,可以有效缩短酒精中毒症状的恢复时间,减少清醒后不适症状发生,缩短肺炎相关症状消失时间,并改善肝功能,减轻炎症反应,值得临床上进一步研究和推广。
【Objective】To investigate the clinical effect of shenmai injection combined with budesnide in the treatment of acute alcoholism complicated with inhalation pneumonia. 【Methods】100 cases of acute alcoholism complicated with inhalation pneumonia met the inclusion criteria were randomly divided into two groups equally. The control group was treated with budesnide, and the observation group was treated with shenmai injection combined with budesnide. Then the clinical effect of treatment of acute alcoholism, disappearance time of pneumonia-related symptoms, change of liver function and inflammatory factors were observed and compared. 【Results】The time for regaining consciousness and recovery time of blood pressure in the observation group were statistically shorter than those in the control group（P〈0.05）. After the consciousness, cases with dizziness, headache or electrolyte disorder were statistically fewer than those in the control group（P〈0.05）. In comparison to the control group, the observation group had a statistically shorter disappearance time of pneumonia-related symptoms, including cough, breathlessness, wheezing rale and moist rale（P〈0.05）. And compared with the group, indices of ALT, AST and GGT reflecting liver function in the observation group were statistically better improved and inflammatory factors of TNF-α, IL-6and CRP were statistically significantly decreased（P〈0.05）.【Conclusion】Clinical effect of shenmai injection combined with budesnide in the treatment of acute alcoholism complicated with inhalation pneumonia was reliable,which could effectively shorten recovering time of alcoholism-related symptoms, decease the incidence of uncomfortable symptoms after consciousness, shorten the disappearance time of pneumonia-related symptoms, improve liver function and alleviate inflammatory reaction.
出处
《中国现代医学杂志》
CAS
北大核心
2015年第7期100-103,共4页
China Journal of Modern Medicine
