摘要
毛细管电泳中的非接触电导检测技术自1998年问世以来受到了广泛的关注。随着理论研究的深入,检测器的设计不断改进以提高其响应灵敏度,同时使它更便于和已有的仪器设备联用,并应用于微流控芯片电泳中。分析对象也从最初的小无机离子拓展到有机组分和生物大分子,随着商品化检测器的出现,该技术趋于成熟。该文侧重介绍近年来有关该传感器的设计改进、与其它检测器联用、与样品富集技术联合方面的研究和应用进展。
The popularity of contactless conductivity detection in capillary electrophoresis has been growing steadily since its introduction in 1998. Improvements have been made in the design of the detector in order to facilitate its handling, to allow easy incorporation into available instruments or to achieve higher sensitivity. The understanding of its fundamental working principles has been advanced and the detection approach has also been transferred to lab-on-chip devices. The range of applications has been extended greatly from the initial work on small inorganic ions to include organic species and biomolecules. Commercial devices are now available and the method can be considered a mature detection technique. In this article, the achievements in design of the detector, combination with other detection methods and samole Dreconcentration techniaues are reviewed.
出处
《化学传感器》
CAS
2014年第4期1-13,共13页
Chemical Sensors
基金
国家自然科学基金资助项目(21275091
21175084)
关键词
非接触电导检测
毛细管电泳
微流控芯片电泳
联用技术
contactless conductivity detection
capillary electrophoresis
microchip capillary eleetrophoresis
combination technique
