摘要
目的探讨抑郁症患者快眼动睡眠潜伏期（REML）与文拉法辛疗效的关系。方法根据REML长短将入组患者分为2组,REML缩短组（REML﹤70 min）25例,REML正常组（70~90 min）25例。在文拉法辛治疗前及治疗后第1、2、4、6周末根据汉密尔顿抑郁17项量表（HAMD-17）得分进行疗效评定,并对基线REML和6周末疗效（减分率）进行相关分析。结果 6周末,2组组内治疗前后比较差异有统计学意义（P〈0.01）。治疗第1、2、4、6周,组间减分无统计学意义（P〉0.05）,疗效相当（P〉0.05）。相关分析显示基线REM L长短与6周末疗效之间不存在明显相关（r=0.155,P=0.282）。结论不能单纯通过基线REML长短来预测文拉法辛的临床疗效,基线REML与文拉法辛疗效之间不存在明显相关。
Objective To investigate the relationship between Rapid Eye Movement latency and the antidepressant effect of Venlafaxine in Depressive Patients. Methods According to the length of the REM sleep latency（ REML）,all patients took Venlafaxine were divided into two groups,25 patients with shortened REML and 25 patients w ith normal REML. The efficacy w as measured with the Hamilton Depression Scale（ HAMD-17） at baseline and on w eeks 1,2,4 and. 6. Then used correlation analysis by examining the REM L and efficacy relationship. Results The HAMD scores of two groups decreased significantly from the first weekend to the sixth weekend（ P 0.01）. There were no significant differences in the 1,2,and 4,6 weeks medication between two groups（ P 0.05）,and they have the same clinical effect（ P 0.05）. The efficacy of sixth weekend has no significant correlation with REML before treatment（ r =- 0.129,P = 0.372）. Conclusion REML before treatment could not exactly predict the response to the treatment with Venlafaxine and there was no significant correlation with REML and the efficacy of sixth weekend.
出处
《世界睡眠医学杂志》
2014年第5期277-280,共4页
World Journal of Sleep Medicine
关键词
抑郁症
快眼动睡眠潜伏期
文拉法辛
临床疗效
Depression
Rapid Eye Movement sleep latency
Venlafaxine
Clinical effect
