摘要
目的分析三阴乳腺癌的临床特征、预后影响因素以及Ki-67在三阴乳腺癌中的表达意义。方法回顾性分析2006年1月-2011年12月安徽医科大学附属巢湖医院79例三阴乳腺癌患者（三阴乳腺癌组）的临床特点、病理特征以及随访情况,并与同期355例非三阴乳腺癌患者（非三阴乳腺癌组）相比较。结果三阴乳腺癌组的远处转移率明显高于非三阴乳腺癌组,差异有统计学意义（16.5%比7.0%,P=0.007）;三阴乳腺癌组患者的5年无病生存率（DFS）和总生存率（OS）分别为69.4%和73.2%,均显著低于非三阴乳腺癌组（84.8%、89.1%,P=0.020、0.012）;进一步分层显示,淋巴结阳性的乳腺癌患者中,三阴乳腺癌组的DFS和OS亦显著低于非三阴乳腺癌组（57.9%比76.4%,P=0.023;65.2%比83.4%,P=0.032）;而在淋巴结阴性的乳腺癌患者中,三阴乳腺癌组的DFS显著低于非三阴乳腺癌组（74.7%比89.8%,P=0.039）,但OS并无显著差异（82.0%比93.5%,P=0.313）。Ki-67在三阴乳腺癌中的表达显著高于非三阴乳腺癌（P〈0.05）。结论三阴乳腺癌的患者具有年轻化、T分期较晚、淋巴结转移率较高等临床特点,其DFS及OS均低于非三阴性乳腺癌患者。其中肿块大小和淋巴结转移状况是影响三阴乳腺癌患者预后的重要因素。Ki-67在三阴乳腺癌中过表达,对三阴乳腺癌的复发转移以及预后有一定意义,是综合评价三阴乳腺癌的临床重要标志物。
Objective To analyze the clinical characteristics and prognostic factors of the patients with triple-negative breast cancer（TNBC）, as well as expression meaning of Ki67 in patients with TNBC. Methods Clinical features, pathological characteristics and follow-up situation of 79 patients with triple negative breast cancer（TNBC group） from January 2006 to December 2011 in the Affiliated Chaohu Hospital of Anhui Medical University were retrospectively analyzed, and compared with 355 patients with non-TNBC（non-TNBC group） in same period. Results The distant metastasis rate of patients in TNBC group was significantly higher than that of the non-TNBC group（16.5% vs 7.0%, P =0.007）. The 5-year disease-free and overall survival rates were both significantly lower in TNBC group than those of the non-TNBC group（69.4% vs 84.8%, P=0.020; 73.2% vs 89.1%, P=0.012）. Among the breast cancer patients with lymph node positive, the 5-year disease-free and overall survival rates were also both significantly lower in TNBC group than those of the non-TNBC group（57.9% vs 76.4%, P=0.023; 65.2% vs 83.4%, P=0.032）. However, although the 5-year disease-free rate of the TNBC group with lymph node negative was significantly lower than the non-TNBC group with lymph node negative（74.7% vs 89.8%, P=0.039）, there was no significant difference in overall survival rate between TNBC group and non-TNBC group with lymph node negative（82.0% vs 93.5%, P=0.313）. The expression of Ki67 in TNBC group was significantly higher than that in the non-TNBC group（P〈 0.05）. Conclusion Patients with TNBC cohorts are usually younger, with advanced tumor stage, higher metastasis rates and so on. The 5-year diseasefree survival and overall survival rates of patients with TNBC were both significantly lower than the patients with nonTNBC. Among them, tumor size and lymph node metastasis situation are the important prognostic factors of influencing TNBC cohort survival. The expression of Ki67 has a certain meaning towards recurrence,
出处
《中国医药导报》
CAS
2015年第6期35-39,共5页
China Medical Herald
基金
安徽省巢湖市科技局科研基金项目(编号:巢科[2011]14号)
关键词
三阴乳腺癌
临床特征
预后因素
KI67
免疫组织化学
Triple-negative breast cancer
Clinical characteristics
Prognosis
Ki67
Histochemistry
