摘要
目的：探索脓毒症患者发生高钠血症的危险因素，及合并高钠血症对脓毒症患者预后的影响。方法通过使用单因素以及多因素Logistic回归分析来明确脓毒症患者10个危险因素与合并高钠血症的关系，包括年龄、性别、急性生理与慢性健康状况评分Ⅱ（ APACHEⅡ评分）、C反应蛋白（ CRP）水平等；同时，比较高钠血症组与非高钠血症组28 d死亡率、住院时间等预后指标。结果 APACHEⅡ评分是脓毒症患者发生高钠血症的独立危险因素（ OR 1．15；95％C I 1．022-1．294）；高钠血症的脓毒症患者住院时间以及机械通气时间明显延长，死亡率明显升高。结论 APACHEⅡ评分是预测脓毒症患者发生高钠血症的独立危险因素，同时与未发生高钠血症的患者比较，合并高钠血症的患者临床预后差。
Objective We aim to explore the risk factors for developing hypernatremia in patients with sepsis and the prognosis of sepsis patients with or without hypernatremia was also assessed. Methods To analyze the data from patients with sepsis, both univariate and multivariate logistic regression analyses were applied, using 10 indices, including age, gender, Acute Physiology and Chronic Health EvaluationⅡ scores （ APACHEⅡ） , C -reactive protein （ CRP ） levels and so on. Clinical prognosis such as mortality, hospital duration of patients with or without hypernatremia was also compared.Results APACHEⅡ score [ odds ratio（ OR ） 1.15; 95% confidence interval （ CI ） 1.022-1.294] was found to be the only independent risk factor for hypernatremia in patients with sepsis.Moreover, these patients with hypernatremia showed significantly longer length of hospital stay and mechanical ventilation （ MV） time and higher rates of complications and mortality .Conclusion APACHEⅡscore is an independent risk factor for hypernatremia in patients with sepsis .Moreover,the clinical outcome of patients with hypernatremia is significantly poorer than the non -hypernatremia group.
出处
《中国急救医学》
CAS
CSCD
北大核心
2015年第3期203-206,共4页
Chinese Journal of Critical Care Medicine
基金
江苏省中医药管理局课题资助（LZ13073）
