摘要
目的：探讨冠心病患者维生素D（VitD）浓度与颈动脉内中膜厚度（IMT）的关系,评价VitD可否作为动脉粥样硬化的预测指标。方法：对临床确诊的462例冠心病患者检测血糖、血脂、C反应蛋白（CRP）、甲状旁腺素（PTH）等生化指标,测定血清VitD的浓度,超声测量颈动脉IMT。根据血清VitD浓度的四分位数将462例患者分为四组（Q1-Q4组）,分析VitD浓度与颈动脉IMT的相关性。结果：VitD低、高浓度组相比,颈动脉IMT、颈动脉斑块发生率、血糖、CRP、PTH差异均有统计学意义。Q1、Q2组颈动脉IMT明显高于Q4组;Q1组的颈动脉斑块发生率明显高于明显高于Q3、Q4组。Pearson相关分析显示颈动脉IMT与年龄、吸烟、体重指数、血糖、CRP、PTH/VitD成正相关,与VitD浓度成负相关。结论：冠心病患者VitD是颈动脉IMT厚度增加的独立危险因素,VitD可作为全身动脉粥样硬化的预测指标。
Objective：Was to research the predictive value of Vitamin D for atherosclerosis by the relationship between level of Vit D and IMT.Methods：Blood sugar,blood fat,CRP,PTH,Vit D were tested in all 462 patients with coronary heart disease who were divided into 4groups according to the serial level of Vit D.Results：Five indicates including IMT,rate of carotid artery plaque（CAP）,blood sugar,CRP,PTH had significant difference between the lower-Vit D and high-Vit D group.IMT in group Q2 was significant higher than that in group Q3 and Q4.There were positive correlation between IMT and age,smoking,BMI,CRP,PTH/Vit D,but negative correlation between IMT and Vit D level by Pearson analysis.Conclusion：Vit D level is independently associated with IMT and could be used to predict atherosclerosis.
出处
《陕西医学杂志》
CAS
2015年第3期321-323,共3页
Shaanxi Medical Journal
