摘要
目的探讨目前部分心血管病治疗药物可能引起肿瘤风险的相关性。方法纳入心血管疾病药物治疗的患者共15512例,根据患者服用不同药物进行分组:服用血管紧张素Ⅱ(AngⅡ)1型受体阻滞剂类药物组3257例,服用伊泽替米类降血脂药物组2364例,服用他汀类药物组2832例,服用利尿剂类药物组2571例,服用噻吩并吡啶类(普拉格雷)药物组2504例,服用安慰剂组1984例。对所有患者随访3年,并记录各组患者在1、2及3年末发生各类肿瘤性疾病占总人数的百分比,meta分析所用心血管药物与肿瘤风险的关系。结果在AngⅡ组患者中,3年末发生肿瘤的例数分别为78、135和231例;伊泽替米组患者3年末发生肿瘤的例数为53、112和185例;他汀类药物组患者在3年末发生肿瘤的例数为22、46和79例;利尿剂组患者在3年末发生肿瘤的例数为25、61和112例;普拉格雷组患者在3年末发生肿瘤的例数为13、31和59例;安慰剂组患者在3年末发生肿瘤的例数为21、52和83例。结论血管紧张素Ⅱ1型受体阻滞剂、伊泽替米类药物可增加肿瘤发生率,他汀类、普拉格雷可减少肿瘤发生率,利尿剂类药物与肿瘤发生风险未见明显相关。
Objective To analyze of the relationship between cardiovascular drug treatment and cancer risk.Methods 15512 patients with cardiovascular disease were divided into angiotensin II（Ang II）type 1 receptor blocker drugs group（3257 cases）,ezetimibe group（2364 cases）,statinsgroup（2832 cases）,diuretic group（2571 cases）,thienopyridine group（2504）,placebo group（1984）.All patients were followed up for 3 years.The relationship between cardiovascular drugs and tumor was analyzed.Results In the Ang II group,there were 78 cases,135 cases and 231 cases occurred tumors at the end of 1 year,2 years and 3 years.In ezetimibe group,there were 53 cases,112 cases and 185 cases occurred tumors at the end of 1 year,2 years and 3 years.In statin group,there were 22 cases,46cases and 79 cases occurred tumors at the end of 1 year,2 years and 3years.In diuretic group,there were 25 cases,61 cases and 112 cases occurred tumors at the end of 1 year,2 years and 3 years.In prasugrel groups,there were 13 cases,31 cases and 59 cases occurred tumors at the end of 1 year,2 years and 3 years.In placebo group,there were 21 cases,52 cases and 83 cases occurred tumors at the end of 1 year,2 years and 3 years.Conclusion We found that angiotensin II type 1 receptor blocker,Ezetimibe for M drugs can increase the tumor incidence,statins,prasugrel reduced tumor incidence,and diuretic drug use have no significant correlation with cancer risk.
出处
《西部医学》
2015年第3期449-451,454,共4页
Medical Journal of West China
基金
国家自然科学基金(81100071)
关键词
肿瘤
心血管病
治疗药物
Tumor
Cardiovascular disease
Medication
