摘要
诱导神经干细胞(induced neural stem cells,i NSCs)是通过在成体细胞内转入特定外源因子而获得。目前主要有两种途径获得i NSCs,即直接诱导法和间接诱导法(需经历重编程过程中不稳定的中间状态)。与诱导多能干细胞(induced pluripotent stem cells,i PSCs)、胚胎干细胞(embryonic stem cells,ESCs)比较,i NSCs直接将成体细胞重编程为神经干细胞,而不经过i PSCs再分化为神经干细胞,可减少其致瘤性,缩短诱导周期,提高转分化效率,这将使其更适于临床应用。本文就i NSCs的研究进展,应用前景加以综述。
It has been reported that induced neural stem cells（ i NSCs） can be obtained from rodent and human somatic cells through the forced expression of defined factors. Two different approaches have been successfully used to obtain i NSCs： a direct method and an indirect method which involves an unstable intermediate state. Compared with induced pluripotent stem cells（ i PSCs） and embryonic stem cells（ ESCs）,i NSCs are committed towards neural lineage,enabling them with a lower risk of tumorigenicity and more efficient transdifferentiation which makes it suitable for clinical use in the future.
出处
《中国比较医学杂志》
北大核心
2015年第2期67-70,共4页
Chinese Journal of Comparative Medicine
基金
973计划重点项目(2012CBA01307)帕金森氏病干细胞治疗的研究
关键词
诱导神经干细胞
体细胞重编程
诱导多能干细胞
治疗
Induced neural stem cells
Somatic cell reprogramming
Induced pluripotent stem cells
Therapy
