摘要
目的探讨不同剂量雌激素替代疗法治疗围绝经期综合征的效果。方法围绝经期综合征患者70例根据随机抽签原则分为治疗组与对照组各35例,对照组给予大剂量雌激素替代疗法治疗,治疗组给予小剂量雌激素替代疗法治疗,都治疗1个月。结果治疗后治疗组与对照组的有效率分别为97.1%和85.7%,组间比较差异明显,治疗组的有效率明显高于对照组(P<0.05)。两组治疗前的血清FSH和E2值比较差异无统计学意义,治疗后FSH值明显降低,E2值明显上升(P<0.05),同时治疗组的血清FSH和E2值与对照组比较,差异有统计学意义(P<0.05)。结论小剂量雌激素替代疗法治疗围绝经期综合征具备更好的疗效,能促进体内激素分泌的正常化,值得推广应用。
Objective To investigate the effectiveness of different doses of estrogen replacement therapy for perimenopausal syndrome. Methods 70 perimenopausal syndrome patients based on a random draw principles were equally divided into treatment group and control group, the control group was given large doses of estrogen replacement therapy, the treatment group was given small dose of estrogen replacement therapy, the treating cycles were months. Results After treatment, the response rates of treatment group and the control group were 97.1% and 85.7% respectively compared to had obvious differences（P〈0.05）. Compared of serum FSH and E2 values between the two groups were not statistically significant before treatment, after treatment FSH values were significantly lower, E2 values were significantly increased（P〈0.05）, and the serum FSH and E2 values simultaneously compared with the control group differences were statistics significance（P〈0.05）. Conclusion Low-dose estrogen replacement therapy for perimenopausal syndrome has better outcomes, it can to promote the normalization of hormone secretion that should be widely applied.
出处
《中国医药科学》
2015年第2期73-75,共3页
China Medicine And Pharmacy
关键词
剂量
雌激素替代疗法
围绝经期综合征
Dose
Estrogen replacement therapy
Perimenopausal syndrome
