摘要
目的探讨舒芬太尼复合地佐辛应用于开胸手术患者术后自控静脉镇痛(PCIA)的效果。方法择期行开胸手术的患者120例,随机分为三组,每组40例,术后均行PCIA。镇痛药配方:A组,舒芬太尼复合地佐辛组,舒芬太尼1.25μg/kg+地佐辛0.4 mg/kg+昂丹司琼8 mg+生理盐水稀释至100 ml;B组,舒芬太尼组,舒芬太尼2.5μg/kg+昂丹司琼8 mg+生理盐水稀释至100 ml;C组,地佐辛组,地佐辛0.8 mg/kg+昂丹司琼8 mg+生理盐水稀释至100 ml。术中采用静吸复合全身麻醉,术毕接PCIA镇痛。观察三组患者术后4、8、12、24、48 h视觉模拟评分(VAS)、镇静程度评分(Ramsay)及不良反应的情况。结果在术后4、8、12 h时间点C组VAS评分高于A组和B组(P<0.05)。术后4、8、12 h时间点B组和C组Ramsay评分高于A组(P<0.05)。B组患者头晕嗜睡、恶心呕吐发生率明显高于A、C组(P<0.05)。结论舒芬太尼复合地佐辛可以安全有效地用于开胸手术术后镇痛,镇痛效果较好,不良反应少。
Objective To explore the effect of sufentanil combined with dezocine applied in postoperative patient controlled intravenous analgesia（PCIA） for patients undergoing thoracotomy. Methods A total of 120 patients, who underwent thoracotomy, were randomly divided into three group with 40 cases in each group. They all received PCIA. The analgesic formula for group A, as sufentanil combined with dezocine group, was sufentanil 1.25 μg/kg ＋ dezocine 0.4 mg/kg＋ondansetron 8 mg, diluted to 100 ml by normal saline; that for group B, as sufentanil group, was sufentanil 2.5 μg/kg＋ondansetron 8 mg, diluted to 100 ml by normal saline; and that for group C, as dezocine group, was dezocine 0.8 mg/kg＋ondansetron 8 mg, diluted to 100 ml by normal saline. Intravenous inhalation anesthesia and general anesthesia were applied during surgery and PCIA after surgery. Visual analogue scale（VAS）, degree of sedation scores（Ramsay）, and adverse reactions were observed in 4 h, 8 h, 12 h, 24 h, and 48 h after surgery in the three groups. Results In postoperative 4 h, 8 h and 12 h, group C had higher VAS score than groups A and B（P〈0.05）, and groups B and C had higher Ramsay scores than group A（P〈0.05）. Group B had higher incidences of drowsiness, dizziness, nausea, and emesis than groups A and C（P〈0.05）. Conclusion Sufentanil combined with dezocine in PCIA for thoracotomy is safe and effective, with good analgesic effect and few adverse reactions.
出处
《中国实用医药》
2015年第4期20-21,共2页
China Practical Medicine
关键词
舒芬太尼
地佐辛
术后镇痛
Sufentanil
Dezocine
Postoperative analgesia
