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联合手术治疗伴玻璃体积血的新生血管性青光眼 被引量:3

Combined surgery for the treatment of neovascular glaucoma with vitreous hemorrhage
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摘要 目的观察联合手术治疗伴玻璃体积血的新生血管性青光眼的临床疗效。方法伴玻璃体积血的新生血管性青光眼26例(26只眼),年龄36~63岁,平均(51.97±7.60)岁。治疗前logMAR最佳矫正视力平均为(2.62±0.43),眼压平均为(46.38±6.75)mmHg(1mmHg=0.133kPa),虹膜及前房角广泛新生血管,玻璃体积血,眼底不能清楚视及。26只眼均行雷珠单抗(Lucentis)0.5mg(0.05m1)玻璃体内注射,注射后5~7d行玻璃体切除联合晶状体切除、广泛视网膜光凝及小梁切除术。结果随访6~12个月,平均(8.69±2.56)月。26只眼的logMAR最佳矫正视力平均为(1.26±0.36),较治疗前高(t=6.13,P=0.00),其中,22只眼视力有不同程度的提高(84.62%),4只眼视力无明显变化(15.38%),未见术后视力下降的情况。26只眼的平均眼压为(18.65±0.56)mmHg,较治疗前低(£:6.61,P=0.00)。26只眼虹膜及前房角的新生血管于雷珠单杭玻璃体内注射后1周内完全或部分消退。治疗过程中未发现严重的眼部或全身并发症。结论对于伴玻璃体积血的新生血管性青光眼,行雷珠单抗玻璃体内注射联合玻璃体切除、晶状体切除、广泛视网膜光凝及小梁切除术,能促使新生血管消退,有效控制眼压,一定程度上提高患者的视力,未发现严重并发症。 Objective To observe the effects of combined surgery for neovascular glaucoma (NVG) with vitreous hemorrhage. Methods Twenty-six eyes of 26 patients of NVG with vitreous hemorrhage underwent intravitreal injection of 0.5rag (0.05ml) Lucentis combined with vitrectomy, lensectomy, panretinal photocoagulation and trabeculectomy. The patients aged from 36 to 63 years old with average age of (5 1. 97 ±7.60 ) years old. The best corrected visual acuity ( BCVA ) of log MAR was (2.62±0.43 ) and the intraocular pressure (IOP) was (46.38 ± 6.75 ) mmHg ( 1 mm Hg : 0. 133 kPa). Results The follow- up period ranged from 6 to 12 months with average (8.69 ±2.56) months. The mean postoperative log MAR BCVA of 26 eyes was significantly improved as ( 1. 26 ± 0. 36 ), and the difference was statistically significant compared with that before treatment (t = 6. 13, P = 0.00). The log MAR BCVA improved in 22 eyes (84.62%) , and remained stable in 4 eyes ( 15.38% ). The mean postoperative IOP was ( 18.65 -+± 0.56) mmHg which was significantly lower than preoperative one (t = 6.61, P = 0. 00). The neovascularization of iris and anterior chamber angle in all patients completely or partly disappeared one week ~ after Lucentis injection. No serious complication occurred. Conclusion lntravitreal injection of Lucentis combined with vitrectomy, Lensectomy, panretinal photocoagulation, and trabeculectomy can control IOP well and improve BCVA without severe complication for NVG patients with vitreous hemorrhage.
出处 《中华眼外伤职业眼病杂志》 2015年第2期86-89,共4页 Chinese Journal of Ocular Trauma and Occupational Eye Disease
基金 基金项目:河南省科技攻关项目(142102310110),河南省教育厅科技攻关项目(14A320084),河南省医学科技攻关项目(201304007)
关键词 青光眼 新生血管性 玻璃体积血 雷珠单抗(Lucentis) 玻璃体内注射 玻璃体切除术 Glaucoma, neovascular Hemorrhage, vitreous Lucentis Injection,intravitreal Vitrectomy
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