摘要
炎症是许多病理状态中机体对有害刺激的应答。例如,一些肿瘤在发生前或发生时常有慢性炎症。据报道,慢性炎症与1/4以上的肿瘤发生相关,相当于全世界每年约320多万人罹患炎症相关的肿瘤[1]。如石棉吸入与间皮瘤,二氧化硅吸入、吸烟、支气管哮喘与支气管癌,宫颈炎、HPV感染与宫颈癌,盆腔炎及卵巢上皮炎症与卵巢癌,EB病毒感染与鼻咽癌,HIV感染与卡西波肉瘤,返流性食管炎与食管癌,幽门螺旋杆菌感染相关性胃炎与胃癌,
The morbidity of inflammation-associated tumor is high. Prevention and treatment of inflammation play a positive role in delaying the occurrence and development of cancer. Antrodia camphorata,an endemic fungus in Taiwan,possesses significant anti-inflammatory effect. So far, 35 anti-inflammatory active components from Antrodia camphorata have been identified,among which triterpenoids account for the most. Studies have revealed that triterpenoids,including ergostanes and lanostanes,have significant anti-inflammatory activities. Because of their structures,especially those of the ergostanes,are similar to the structures of cholesterol and steroid hormones,their anti-inflammatory mechanism may be related to mimic the steroid hormones or interfere with the effect of cholesterol.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2015年第2期369-373,共5页
Chinese Journal of Pathophysiology
关键词
樟芝
三萜类化合物
炎症
Antrodia camphorata
Triterpenoids
Inflammation
