摘要
生长发育受损为儿童炎症性肠病(inflammatory bowel disease,IBD)的特征表现,常见于克罗恩病,对患儿的生活质量、情绪功能、社会功能和身体形象具有负面影响.其发病机制尚不明确,可能由营养不良、炎症、糖皮质激素等多因素影响生长激素/胰岛素样生长因子-1轴或生长板所致.目前治疗主要包括营养支持治疗、生物制剂、手术切除、激素治疗等.针对儿童IBD生长发育受损的长期监测、治疗,尚需制定统一标准.由医院、家庭和社会共同努力实现最佳生长.
Growth failure associated with delayed puberty is a unique feature in pediatric patients with inflammatory bowel disease （IBD）, especially those with Crohn’s disease, which has a negative effect on quality of life, emotional functioning, social functioning, and body image. Although the underlying mechanisms are not fully clear, the condition may be induced by the effects of malnutrition, inflammatory process and glucocorticoid on the growth hormone/insulin-like growth factor-1 axis or on the growth plate. Nutrition, biologic agents, intestinal resection and glucocorticoids are main treatments. Standards for monitoring and treatment of impaired growth and development in pediatric IBD patients need to be formulated. To achieve optimal growth, the efforts of hospitals, families and society are necessary.
出处
《世界华人消化杂志》
CAS
2015年第2期221-228,共8页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
Nos.81160055
81260074
云南省科技厅-昆明医学院联合专项基金资助项目
Nos.2011FB183
2007C0010R
云南省卫生厅卫生系统学科带头人培养计划基金资助项目No.D-201215
云南省社会发展科技计划基金资助项目
No.2013CA021~~
关键词
儿童
炎症性肠病
生长受损
发育迟缓
病因
治疗
Children
Inflammatory bowel disease
Growth failure
Delayed puberty
Etiology
Treatment
