摘要
目的 探讨帕金森病（PD）患者血清脂联素水平与运动症状以及非运动症状的相关性.方法 选取94例PD患者以及90名健康对照者,利用ELISA法检测PD患者及健康对照者血清脂联素水平,并记录PD患者的年龄、多巴丝肼片剂量,并对所有PD患者行帕金森病评价量表第三部分评分（UPDRSⅢ）、Hoehn-Yahr分期、ADL、Webster、疲劳严重度量表（FSS）、匹茨堡睡眠质量指数（PSQI）、自主神经功能量表（SCOPA-AUT）、汉密尔顿抑郁量表（HAMD）评估.结果 PD患者血清脂联素水平为（8.2±2.6）mg/L,明显低于健康对照组的（17.5±7.1）mg/L,且差异有统计学意义（t=-4.12,P＜0.01）.脂联素水平与PD患者的UPDRSⅢ评分、H-Y分期、Webster评分、ADL评分及PSQI评分均呈负相关（r分别为-0.71,-0.82,-0.77,-0.64,-0.69;P＜ 0.05）.结论 PD患者血清脂联素水平降低,且与PD患者的运动症状及非运动症状均有关.
Objective To explore the correlation between serum adiponectin level and motor symptoms and non--motor symptoms in patients with Parkinson＇s disease （PD）. Methods Ninety--four PD patients and Ninety healthy controls admitted to our hospital were involved in this study. Serum adipone- ctin levels were measured by ELISA methods in patients with PD and healthy controls. The age, gender, madopa tablets dose of PD patients were recorded. In addition, part III of Unified Parkinson disease rating scale （UPDRS） scores, Hoehn-Yahr （H-Y） stage, Activity of Daily Living Scale （ADL） scores, Webster scores, Fatigue severity scale （FSS） scores, Pittsburgh sleep quality index （PSQI） scores, SCOPA--AUT scores and Hamilton Depression Scale （HAMD） scores were evaluated in PD patients. Results The serum levels of adiponectin were （8.2±2.6）mg/L in PD patients, significantly lower than healthy controls （17. 5 ±7. 1）mg/L, and the difference was statistically significant （t =- 4.12, P 〈 0.01）. There was a negative correlation between serum levels of adiponectin and UPDRS scores, H-Y stage, Webster scores, ADL scores and PSQI scores （r =- 0.71, -0. 82, -0. 77, -0. 64, -0.69, respectively; P 〈 0.05）. Conclusions Serum adiponectin levels were decreased in PD patients. There was a correlation between serum adiponectin levels and motor symptoms as well as non-motor symptoms in patients with PD.
出处
《神经疾病与精神卫生》
2015年第1期9-11,共3页
Journal of Neuroscience and Mental Health
基金
国家自然科学基金资助项目（81301077）
江苏省高校自然科学基金（13KJB320026）
关键词
帕金森病
脂联素
运动症状
非运动症状
Parkinson disease
Adiponectin
Motor symptom
Non--motor symptom
