摘要
目的分析中医药配合奈达铂联合多西他赛方案治疗晚期非小细胞肺癌的近期疗效。方法收集127例晚期NSCLC患者,采用随机数字表法将其分为中西医结合组（65例）和化疗组（62例）,观察两组患者的近期疗效、症状改善、生活状态和毒副反应等。结果全部127例患者均可评价疗效,无治疗相关死亡。中西医结合组患者完全缓解（CR）3例,部分缓解（PR）31例,疾病稳定（SD）20例,客观有效率为占52.3%,明显优于化疗组的33.9%（χ^2=4.393,P=0.027）。中西医结合组患者的疾病控制率为83.1%,明显优于化疗组的58.1%（χ^2=9.616,P=0.002）。在中西医结合组治疗后咳嗽、咳痰、咳血、胸痛、发热、气短等的改善均优于化疗组,差异有明显统计学意义（P〈0.01）。中西医结合组疗程结束后Karnofsky评分提高及稳定率优于化疗组,差异有统计学意义（P〈0.05）。中西医结合组的白细胞降低、血小板下降、血红蛋白减少、恶心呕吐、便秘和肝功能异常发生率分别为43.1%、38.5%、33.9%、24.6%、7.7%和12.3%,均分别低于化疗组的90.3%、87.1%、74.2%、72.6%、69.4%和59.7%,两组差异有统计学意义（P〈0.01）。中西医结合组不良反应多为Ⅰ-Ⅱ度。结论中医辨证施治配合高效低毒的二代含铂化疗方案治疗晚期非小细胞肺癌可进一步提高近期疗效,明显改善患者生存质量,减少不良反应。
Objective To investigate the short-term effect and the influence on improvement of symptoms,toxic effects of traditional chinese medicine combined with the high-efficiency,second-generation platinum-based chemotherapy in advanced non-small cell lung cancer（ NSCLC）. Methods A total of 127 patients with advanced NSCLC were randomly divided into cooperation of Chinese and Western medicine treatment group（ n = 65） and chemotherapy group（ n = 62）,Short-term effect,symptom inprovement,living conditions,adverse reactions in two groups were compared. Results All 127 patients had been evaluated,and no treatment-related deaths were reported. Overall response rate（ 52. 3% vs 33. 9%,P = 0. 027）and disease control rate（ 83. 1% vs 58. 1%,P = 0. 002） of cooperation of Chinese and Western medicine treatment group were significantly higher than that in chemotherapy group. The symptoms of cough,ecpectoration,hemoptysis,chest pain,fever,and shrotness of breath in the cooperation of Chinese and Western medicine treatment group were inferior to chemotherapy group（ P〈0. 01）. Karnofsky score increase and stable rate in the cooperation of Chinese and Western medicine treatment group is better than that in chemotherapy group（ P〈0. 01）. The decrease of white blood cell and platelet decline,decreased hemoglobin,nausea and vomiting,constipation,abnormal liver function of cooperation of Chinese and Western medicine treatment group were 43. 1%,38. 5%,33. 9%,24. 6%,7. 7%,12. 3%,lower than that in chemotherapy group（ 90. 3%,87. 1%,74. 2%,72. 6%,69. 4%,72. 6%）,with significant difference（ P〈0. 01）,and adverse reactions were grade Ⅰ / Ⅱ in cooperation of Chinese and Western medicine treatment group.Conclusions Traditional Chinese medicine dialectical treatment combined with the high-efficiency,secondgeneration platinum-based chemotherapy in advanced NSCLC can efficiently enhance the short-term effect,improve the quality of life,and reduce the indicence of adverse reaction.
出处
《中国肿瘤临床与康复》
2015年第2期171-174,共4页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
肺肿瘤
含铂方案
中医辨证
Lung neoplasms
Platinum-based treatment
Traditional Chinese medicine dialectical treatment
