摘要
目的研究纤体降脂Ⅰ号不同提取物对去卵巢大鼠的影响。方法 270 g左右的SD大鼠100只,♀,按体质量随机选出正常组和假手术组各10只,其余采用双侧去卵巢法,建立去卵巢大鼠模型,灌胃给药干预,连续13周。测定大鼠食量、体质量、腹脂含量、Lee’s指数、血脂、甲状旁腺激素含量。结果各提取物均能抑制模型鼠体质量增长(P<0.05或P<0.01);石油醚提取A部分能明显抑制食量增长(P<0.01),降低腹脂含量和Lee’s指数(P<0.05或P<0.01),显著降低血清LDL-C、TC水平(P<0.01),有抑制子宫萎缩的趋向。结论纤体降脂Ⅰ号各提取物均能抑制模型鼠体质量的增长。石油醚提取A部分能够有效抑制模型鼠体质量和食欲的增加,改善脂代谢紊乱,有抑制子宫萎缩的趋向,可能是纤体降脂Ⅰ号的主要药效物质群。
OBJECTIVE To study the effect of different extracts of Xianti Jiangzhi Ⅰprescription on ovariectomized rats. METHODS All of 100 female SD rats, weighted about 270 g, were divided randomly into 10 groups, ten rats each group. The administration of drugs started 10 days after operation and continued for 13 weeks. In the end, the blood, fact were collected to make the following tests： serum lipids（TC, HDL-C, LDL-C）, wet weight of abdominal fat, et al. RESULTS Every parts can signifycantly control the weight gain of the model rats（P〈0.01）. The part extracted by petroleum ether could control the food intake, lower the content of wet abdominal fat, reduce the lees indexes（P〈0.05 or P〈0.01）, significantly lower the level of serum TC and LDL-C（P〈0.01）.CONCLUSION Every parts can significantly control the weight gain of the model rats. The part extracted by petroleum ether can control the food intake, improve lipid metabolism disorders, it may be the main efficacy part of Xianti Jiangzhi ⅠPrescription.
出处
《中国现代应用药学》
CAS
CSCD
2014年第10期1178-1182,共5页
Chinese Journal of Modern Applied Pharmacy
基金
广东省医学科研基金项目(B2013417)
关键词
纤体降脂Ⅰ号
提取物
去卵巢大鼠
作用机制
Xianti Jiangzhi Ⅰprescription
extracts
ovariectomized rats
effect mechanism
