摘要
目的:观察糖尿病肾病患者血清NT-proBNP,Hcy和cTnI的水平变化情况,分析其与心血管疾病发生的关系,为临床提供指导依据。方法:选择我院2012年3月至2013年9月收治的152例糖尿病肾病患者,根据合并心血管疾病的情况,将所选患者分为并发症组(83例)和无并发症组(69例),另选择同期在我院接受健康体检的志愿者(72例)作为对照组。检测三组对象血清中NT-proBNP,Hcy与cTnI的水平,以及糖尿病肾病患者的肾功能指标。结果:对照组NT-proBNP,Hcy与cTnI水平显著低于其他两组,并发症组患者NT-proBNP,Hcy与cTnI水平高于无并发症组,差异有统计学意义(P<0.05)。并发症组患者的BUN,UA及CysC水平显著高于无并发症组,差异有统计学意义(P<0.05)。结论:NT-proBNP,Hcy和cTnI在合并心血管疾病的糖尿病肾病患者血清中显著升高,并在一定程度上影响患者的肾功能。
Objective： To observe the relationship between changes of NT-proBNP, Hcy and cTnI levels and cardiovascular disease in diabetic nephropathy（DN） patients, and to provide guidance for clinic. Methods： 152 cases of DN patients were divided into complications group（83 cases） and no complication group（69 cases） from March 2012 to September 2013 according to the presence of cardiovascular disease. Meanwhile, 72 cases of healthy patients were chosen as the control group. NT-proBNP, Hcy and cTnI levels were detected of all the patients, so as the renal function indexes in DN patients. Results： NT-proBNP, Hcy and cTnI levels of the control group were lower than that of the other two groups, and higher in complications group than in no complications group with statistical significance（P〈0.05）. BUN, UA and CysC levels in the complications group were higher than in no complication group in DN patients,and the difference was statistically significant（P〈0.05）. Conclusion：NT-proBNP, Hcy and cTnI levels increased significantly in DN patients combined with cardiovascular disease which can affect renal function.
出处
《现代生物医学进展》
CAS
2014年第33期6532-6534,共3页
Progress in Modern Biomedicine
基金
唐山市科学技术研究与发展计划(12150220B-5)
国家自然科学基金面上项目(81270824)
