摘要
目的 探讨应用双水平气道正压通气（BiPAP）无创呼吸机进行序贯通气治疗慢性阻塞性肺疾病急性加重期（AECOPD）并发肺性脑病临床疗效和预后,为临床治疗提供依据.方法 选择AECOPD合并肺性脑病患者62例,随机数字表法分为两组,对照组30例,进行常规治疗;观察组32例,应用BiPAP无创呼吸机序贯通气治疗.观察两组治疗前后PaO2、PaCO2和SaO2;心率、呼吸频率和平均动脉压变化及两组患者主要指标改善时间等.结果 两组治疗后PaO2和SaO2均高于治疗前（t=12.30、10.37、11.42、13.71,均P＜0.05）;治疗后观察组PaO2和SaO2分别为（77.14±4.16） mmHg和（90.37±2.04）％,均高于对照组的（72.96±3.22） mmHg和（85.80±1.96）％（t=6.58、7.14,均P＜0.05）.两组治疗后PaCO2均低于治疗前（t=9.25、10.22,均P＜0.05）;治疗后观察组PaCO2为（50.12±2.86） mmHg,低于对照组的（54.27±3.01） mmHg（t=6.29,P＜0.05）.两组治疗后心率、呼吸频率和平均动脉压均低于治疗前（t=10.11、9.43、8.66、11.28、8.56、9.15,均P＜0.05）;观察组治疗后心率、呼吸频率和平均动脉压分别为（76.52±4.35） 次/min、（20.35 ±1.08）次/min和（83.26±3.07） mmHg,均低于对照组治疗后（t=6.44、5.82、6.70,均P＜0.05）.观察组血气改善时间、呼吸支持时间和住院时间分别为（4.06 ±1.17）d、（4.53 ±0.90）d和（16.18±2.20）d,均短于对照组（t=6.13、7.05、5.97,均P＜0.05）.结论 应用BiPAP无创呼吸机序贯通气治疗AECOPD并发肺性脑病临床疗效较好,可改善患者改善通气困难、避免缺氧和二氧化碳潴留,缩短治疗时间.
Objective To explore the treatment effect and prognosis of BiPAP non-invasive ventilator of sequential mechanical ventilation for the treatment of acute exacerbation of chronic obstructive pulmonary disease （AECOPD） complicated with pulmonary encephalopathy,and to provide the basis for clinical therapy.Methods According to the digital table,62 AECOPD patients with pulmonary encephalopathy were selected and randomly divided into the two groups.And 30 cases in the control group received routine treatment,and 32 cases in the observation group received BiPAP non-invasive ventilator sequential ventilation.The partial pressure of oxygen （PaO2）,partial pressure of carbon dioxide （PaCO2） and oxygen saturation （SaO2） before and after treatment,the changes of heart rate,respiratory rate and average arterial pressure of the two groups and the improvement time were observed.Results PaO2 and SaO2 of the two groups after treatment were higher than those before treatment （t =12.30,10.37,11.42,13.71,all P 〈0.05）.PaO2 and SaO2 of the observation group after treatment were （77.14 ±4.16）mmHg and （90.37 ± 2.04） %,which were higher than the control group after the treatment （72.96 ± 3.22） mmHg and （85.80 ± 1.96） %（t =6.58,7.14,all P 〈 0.05）.PaCO2 of the two groups after treatment was lower than that before treatment （t =9.25,10.22,all P 〈 0.05）.PaCO2 of the observation group after treatment was （50.12 ± 2.86） mmHg,which was lower than that before treatment （54.27 ± 3.01） mmHg （t =6.29,P 〈 0.05）.The heart rate,respiratory rate and mean arterial pressure of the control group and the observation group after treatment were lower than before treatment （t =10.11,9.43,8.66,11.28,8.56,9.15,all P 〈0.05）.The heart rate,respiratory rate and mean arterial pressure of the observation group after treatment were （76.52 ± 4.35） times/min,（20.35 ± 1.08） times/min and （83.26 ±3.07）mmHg,which were lower than those of the control group after treatment （t =6.44,5
出处
《中国基层医药》
CAS
2015年第2期210-212,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
通气机
机械
肺疾病
慢性阻塞性
脑疾病
Ventilators,mechanical
Pulmonary disease,chronic obstructive
Brain diseases
