摘要
目的:探讨老年心脑血管病患者亚甲基四氢叶酸还原酶(MTHFR)基因多态性与血清同型半胱氨酸(HCY)、叶酸的关系。方法:分析286例患者的MTHFRC667T基因多态性,叶酸、维生素B12、HCY水平和大血小板比例。结果:老年心脑血管病患者中MTHFR667基因野生型(C/C型)、杂合突变型(C/T型)、纯合突变型(T/T型)频率分别为28.7%,41.2%,30.1%,且男女间无差异;血清HCY与叶酸、维生素B12呈负相关(P<0.05),T/T型、C/T型的叶酸明显低于C/C型(P<0.05),而比较3型的HCY差异无统计学意义;T/T型的MCV、大血小板比例、FPG、TG、TC、LDL-C明显高于C/T型与C/C型(P<0.05)。结论:老年心脑血管患者的MTHFR基因多态性与血清HCY无关,但与叶酸、维生素B12、血糖血脂和大血小板比例有关。
[Objective]To investigate the relationship between serum folate,homocysteine（HCY）and methylenetetrahydrofolate reductase（MTHFR）genepolym-orphism in elderly patients with cardiovascular and cerebrovascular diseases.[Method]Examine MTHFR gene polymorphism,folate,vitaminB12,HCY and proportion of large platelet.[Result]The frequency of C/C type,C/T type and T/T type was 28.7%,41.2% and30.1%;Homocysteine had negative correlations with vitamin B12 and folate（P〈0.05）,and folate was lower in C/T and T/T type（P〈0.05）,while homocysteine had no differences in three types.MCV,large platelet ratio,FPG,TC,TG and LDL-C in T/T type were higher than others（P〈0.05）.[Conclusion]MTHFR gene polymorphism in elderly patients with cardiovascular and cerebrovascular diseases showed no association with plasma homocysteine,but it was correlated with folate,vitamin B12,blood glucose,blood lipid and the proportion of large platelet.
出处
《浙江医学教育》
2015年第1期43-46,共4页
Zhejiang Medical Education
基金
浙江省医药卫生科学研究基金项目(编号:2012KYB009)
关键词
心脑血管病
MTHFR基因多态性
叶酸
同型半胱氨酸
cardiovascular and cerebrovascular diseases
MTHFR gene polymorph-hism
folate
homocysteine
