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盐酸普萘洛尔对盐酸氟桂利嗪在大鼠体内药物代谢动力学的影响 被引量:1

Effect of propranolol hydrochloride on pharmacokinetics of flunarizine hydrochloride in rats
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摘要 目的研究盐酸普萘洛尔对盐酸氟桂利嗪在大鼠体内药动学行为的影响。方法 10只健康雄性Wistar大鼠平均分成2组,一组灌胃给予盐酸氟桂利嗪(10 mg·kg-1),一组灌胃给予盐酸氟桂利嗪(10 mg·kg-1)和盐酸普萘洛尔(10 mg·kg-1),用HPLC-UV法测定血浆中氟桂利嗪的浓度。结果大鼠给予盐酸氟桂利嗪或同时给予盐酸氟桂利嗪和盐酸普萘洛尔后,主要药动学参数经统计学比较,差异均无统计学意义(P>0.05)。结论盐酸普萘洛尔对盐酸氟桂利嗪在大鼠体内药动学行为没有显著性影响。 Objective To determine the effect of propranolol hydrochloride on pharmacokinetics of flunarizine hydrochloride in rats. Methods Ten male Wistar rats were divided into 2 groups: one group was given flunarizine hydrochloride(10 mg·kg- 1) intragastrically, the other group was given flunarizine hydrochloride(10 mg·kg- 1) and propranolol hydrochloride(10 mg·kg- 1) intragastrically. The plasma concentrations of flunarizine were determined by HPLCUV. Results After giving the rats flunarizine hydrochloride or flunarizine hydrochloride and propranolol hydrochloride, there were no significant differences among the pharmacokinetic parameters(P〉 0.05). Conclusion There is no significant effect of propranolol hydrochloride on the pharmacokinetics of flunarizine hydrochloride in rats.
出处 《中南药学》 CAS 2015年第1期31-33,共3页 Central South Pharmacy
关键词 盐酸氟桂利嗪 盐酸普萘洛尔 高效液相色谱法 药动学 flunarizine hydrochloride propranolol hydrochloride HPLC-UV pharmacokinetics
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