摘要
目的通过高龄孕妇产前胎儿染色体核型结果分析,探讨高龄妊娠胎儿染色体异常的风险。方法采用羊水穿刺术对6 821例高龄孕妇进行细胞遗传学诊断,计算高龄妊娠胎儿染色体异常的比率,同时比较35岁-37岁、38岁-40岁及≥41岁孕妇胎儿染色体异常的发生率,分析不同高龄组胎儿染色体异常的风险比率。结果 6821例高龄孕妇共发现胎儿染色体核型异常321例,染色体异常发生率为4.71%,所有异常核型中,除染色体多态性变异外,以数目异常最为常见,异常构成比为21.81%（70/321）,同时不同年龄组染色体异常的发生率逐渐增高,其中35岁-40岁和≥41岁年龄组的比较差异有统计学意义（P〈0.05）。结论随着孕妇年龄的增长,胎儿染色体异常风险逐渐增高,高龄孕妇应加强产前诊断意识,提高出生人口素质。
Objective Through the karyotype analysis results of the fetal chromosome abnormalities of pregnant women of advanced maternal age,to discuss the risk of chromosome abnormalities of fetus. Methods Cytogenetic diagnosis was conducted in 6 821 pregnant women of advanced maternal age by amniocentesis by amniotic fluid puncture,so as to calculate the abnormal rates of fetus. The study population was divided into three groups according to maternal age： 35- 37 years old,38- 40 years old and over 41 years old. The risk ratio of fetal chromosome abnormalities was analyzed and compared among these three groups. Results Among 6 821 pregnant women of advanced maternal age,321 cases were abnormal karyotypes with the ratio of4. 71%. Among all the abnormal karyotype,the abnormalities in numbers are most common apart from the chromosome polymorphism,with the abnormal composition ratio of 21. 81%（ 70 /321）. At the same time,the incidence of chromosome abnormal was increasing with the growing of pregnant women＇s age. The differences in comparison of 35- 40 and over 41 age groups had statistical significance（ P〈0. 05）. Conclusion Risk of the fetal chromosome abnormalities increases with the growing of advanced maternal age,so the prenatal diagnosis should be performed in every pregnant woman of advanced maternal age,so as to increase the birth quality.
出处
《中国卫生检验杂志》
CAS
2015年第3期378-380,共3页
Chinese Journal of Health Laboratory Technology
关键词
高龄孕妇
染色体核型
产前诊断
Advanced pregnant women
Chromosomal karyotype
Prenatal diagnosis analysis
