摘要
目的探讨甲状腺乳头状癌（PTC）中Notch-1的表达及复发相关因素。方法应用免疫组织化学方法，对235例PTC患者的石蜡组织进行Notch．1的表达检测，结合临床病理及预后资料，分析Notch-1表达与PTC复发的相关性。结果Notch-1在PTC复发患者中表达高于无复发患者（X^2=20．164，P〈0．05）。Notch-1表达、肿瘤大小、原发灶包膜外侵犯、手术方式及T分期与复发相关（P〈0．05），性别、年龄、临床分期、淋巴结转移对复发无明显影响（P〉0．05）。多因素回归分析提示Notch-1表达、原发灶包膜外侵犯是PTC复发的独立因素。结论Notch-1的高表达提示PTC的不良预后，可能为PTC复发患者的有效预后指标。
Objective To analyze the expression of Notch-1 and correlation between Notch-1 expression and recurrence-related factors in papillary thyroid carcinoma （PTC）. Methods Immunohistochemical staining was performed on 235 paraffin tissues to detect the expression of Notch-1. Combining the clinicopathological and prognostic data, the correlation between Notch-1 expression and recurrence was analyzed. Results Notch-1 had higher expression in the relapsed PTC patients than in the patients without recurrence （X^2 = 20.164, P 〈 0.05）. Kaplan-Meier method showed Notch-1 expression, tumor size, extrathyroidal extention （ETE）, surgical procedures and T-classification were statistical significant with recurrence of PTC （P 〈 0.05）. There was no statistical significance between age, gender, TNM stage or lymph node metastasis with recurrence of PTC （P 〉 0.05）. Multiple analysis showed that Notch-1 expression and ETE were the independent factors in relapsed PTC. Conclusion High expression of Notch-1 indicates poor prognosis of PTC and Notch-1 could be an effective indicator for the recurrent PTC.
出处
《肿瘤研究与临床》
CAS
2015年第1期11-14,18,共5页
Cancer Research and Clinic
基金
广东省科技计划
