摘要
目的运用Meta分析方法系统评价复方丹参滴丸治疗糖尿病肾病(DN)的临床疗效。方法计算机检索美国医学文摘数据库(Medline)、中国生物医学文献数据库(CBM)、中国期刊全文数据库(CNKI)、中文科技期刊全文数据库维普(VIP)和万方数字化期刊全文库等数据库,对纳入的随机对照试验文献进行质量评价,并采用Rev Man 5.2软件进行Meta分析。结局指标为尿白蛋白排泄率(UAER)、24 h尿蛋白定量、总胆固醇(TC)和三酰甘油(TG)。结果共纳入14篇随机对照试验,共1 032名患者。Meta分析结果显示,复方丹参滴丸能显著减少DN的UAER[MD=-15.76,95%CI(-17.44,-14.08),P<0.01]、24 h尿蛋白定量[MD=-0.11,95%CI(-0.12,-0.10)]、TC[MD=-0.80,95%CI(-1.42,-0.18),P=0.01]和TG[MD=-0.80,95%CI(-1.42,-0.18),P=0.01]水平。结论复方丹参滴丸能减少DN的尿蛋白和血脂水平;但本研究纳入的研究数量偏少,且方法学上存在缺陷,证据强度不高,因此复方丹参滴丸治疗DN的疗效仍需深入研究。
Objective To evaluate the clinical efficiency of Compound Danshen Dripping Pills in treatment of diabetic nephropathy by Meta analysis. Methods Using computer searches American medical abstract database（Medline）, Chinese biomedical literature database（CBM）, China Journal Full-text Database（CNKI）, Chinese Science and Technology Journal Full-text Database（VIP）, Wanfang Database, etc.And the quality assessment of qualified randomly control trials was evaluated. Meta analysis was carried out by Rev Man 5.2 software. The outcomes included urinary albumin excretion rate（UAER）, 24 h urinary protein excretion, total cholesterol（TC）, and triglyceride（TG）. Results A total of 14 studies were included, involving 1032 patients. Meta analysis showed that Compound Danshen Dripping Pills could significantly decrease in UAER [MD =-15.76, 95%CI（-17.44,-14.08）, P〈0.01], 24 h urinary protein excretion [MD =-0.11, 95%CI（-0.12,-0.10）], TC [MD =-0.80, 95%CI（-1.42,-0.18, P = 0.01] and TG [MD =-0.80, 95%CI（-1.42,-0.18, P = 0.01]. Conclusion Compound Danshen Dripping Pills can decrease the urine protein and blood routine. But the poor methodological quality of included studies seriously weaken the validity of the Meta analysis. So the efficacy of Compound Danshen Dripping Pills in treatment of diabetic nephropathy should be deeply studied
出处
《现代药物与临床》
CAS
2015年第1期89-94,共6页
Drugs & Clinic
关键词
复方丹参滴丸
糖尿病肾病
META分析
Compound Danshen Dripping Pills
diabetic nephropathy
Meta analysis
