摘要
目的：探讨临床应用小剂量甲泼尼龙辅助治疗儿童难治性肺炎支原体肺炎（RMPP）对患儿症状体征、炎症指标及住院时间的影响。方法：选取2013年1月至2014年3月于我院儿科住院的104例RMPP患儿,随机分为对照组51例和观察组53例,对照组予大环内酯类抗生素序贯治疗,观察组在对照组治疗基础上加用甲泼尼龙2 mg/（kg·d）治疗3-5 d,观察临床疗效并比较两组患儿咳嗽缓解时间、体温恢复时间、第10天胸部X线片改善情况、住院时间及治疗前后炎症指标的变化。结果：观察组总有效率为96.2%,高于对照组的86.3%（P〈0.05）;咳嗽缓解时间、体温恢复时间及住院时间均短于对照组（P均〈0.05）;第10天胸部X线片改善情况优于对照组（P〈0.05）;治疗后炎症指标（CRP、LDH、ESR）改善比对照组更明显（P均〈0.01）。结论：小剂量甲泼尼龙辅助治疗儿童RMPP能更快地缓解临床症状,促进炎症吸收,缩短住院时间,不良反应少,值得临床推广应用。
Objective： To explore the clinical effect of low-dose methylprednisolone in adjunctive treatment of children with refractory mycoplasa pneumoniae pneumonia（ RMPP）. Methods： One hundred and four RMPP children who admitted to our department from January 2013 to March 2014 were divided randomly into control group and treatment group. The control group were given macrolide antibiotic sequential treatment and the treatment group was given low-dose methylprednisolone 2 mg /（ kg · d）,for 3 - 5 days. The clinical efficacy,disappearance time of coughing,recovery time of temperature,improvement of X-ray chest film after 10 days treatment,the length of hospitalization,and inflammatory indexes were observed before and after treatment in two groups. Results： The total effective rate of the treatment group was 96. 2%,the control group was 86. 3%,the difference was significant（ P〈0. 05）.Compared with the control group,disappearance time of coughing,recovery time of temperature and the length of hospitalization were significantly shortened in the therapy group（ P〈0. 05）. The improvement of X-ray chest film after 10 days treatment in treatment group was better than that of the control group,the difference was statistically significant（ P〈0. 05）. The levels of CRP、LDH、ESR in treatment group were improved better than that of the control group after treatment（ P〈0. 05）. Conclusion： Low-dose methylprednisolone in adjunctive treatment of children with RMPP can relieve clinical symptoms,promote inflammation absorption and shorten hospital stays,it is worthy of clinical use.
出处
《儿科药学杂志》
CAS
2015年第3期18-21,共4页
Journal of Pediatric Pharmacy
关键词
甲泼尼龙
肺炎支原体
肺炎
辅助治疗
Methylprednisolone
Mycoplasa pneumoniae
Pneumonia
Adjunctive treatment
