摘要
目的探讨胰腺实性假乳头状瘤(SPTP)的临床和病理特征。方法对1例SPTP的临床病理特征和免疫组化进行分析,并结合相关文献进行讨论。结果本例镜下肿瘤细胞围绕小血管形成假乳头状,并见出血、坏死、黏液变性及胆固醇沉积;细胞异型不明显,未见核分裂象。免疫组化染色示抗胰蛋白酶(α-1-AT)、波形蛋白(Vim)、孕激素受体(PR)、神经元特异性烯醇酶(NSE)、细胞角蛋白(CK)、CD56、CK8阳性,S-100局部阳性,CK7、嗜铬素(Cg A)局部弱阳性;突触素(Syn)、甲胎蛋白(AFP)、癌胚抗原(CEA)、雌激素受体(ER)阴性,ki-67<5%。病理诊断为胰腺实性假乳头状瘤。结论 SPTP属胰腺外分泌肿瘤,临床罕见,组织病理学特征有助于诊断。本病预后良好。
Objective To explore the clinical and pathological features of solid pseudopaillary tumor of the pancreas（ SPTP）. Methods The clinicopathologic features and immunohistochemical staining of one SPTP patient were analyzed,and diagnosis and differential diagnoses combined with the literature were reviewed. Results Microscopic examination showed that the pseudopapillary structures were formed by tumor cells wrapping the blood vessels accompanied by haemorrhage,necrosis,mucoid degeneration and cholesterol deposition without cell heteromorphosis or mitosis. The immunohistochemical staining showed that α-1-AT,vimentin（ Vim）,progestogen receptor（ PR）,neuron-specific enolase（ NSE）,creatinine kinase（ CK）,CD56 and CK8 were positive,S-100 was partly positive,CK7 and Cg A were weakly positive in part. Synaptophysin（ Syn）,alpha-fetoprotein（ AFP）,carcinoembryonic antigen（ CEA） and estrogen receptor（ ER） were negative,and ki-67 was less than 5%. The SPTP diagnosis was confirmed by pathological examination. Conclusion The SPTP is a clinically rare exocrine tumor of pancreas,and the pathological features is helpful in diagnosis.SPTP has good prognosis.
出处
《解放军医药杂志》
CAS
2015年第2期107-109,共3页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
关键词
胰腺肿瘤
实性假乳头状瘤
病理学
临床
免疫组化
Pancreatic neoplasms
Solid pseudopaillary tumor
Pathology
clinical
Immunohistochemistry
