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内在凝血途径的接触激活——抗血栓形成研究的新靶点 被引量：5

Intrinsic Clotting Pathway Activation Contact-Anti Thrombosis Research new Targets
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摘要 内在凝血途径接触激活的启动因子是凝血因子XII（FXII）,激活的FXIIa催化底物是FXI。但由于FXII缺陷并无出血倾向,FXI缺陷的出血倾向远较FⅧ与FIX缺陷为低。因此,长期以来对于内在途径接触环节的生物医学意义存在疑问。近十余年来,由于分子生物学技术和其它先进手段的广泛应用,对此研究有了突破性进展[1-6]。
作者 贺石林 王东生 文志斌 何晓凡
机构地区 中南大学湘雅医学院止血生理研究室 中南大学湘雅医院中西医结合研究所
出处 《血栓与止血学》 2015年第1期57-64,共8页 Chinese Journal of Thrombosis and Hemostasis
关键词 内在凝血途径 接触激活 抗血栓形成 新靶点
分类号 R331 [医药卫生—人体生理学]
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参考文献96

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二级参考文献33

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共引文献4

同被引文献38

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二级引证文献18

血栓与止血学
2015年 第1期

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