摘要
目的:探讨诱捕受体3(Dc R3)蛋白在胆囊癌组织中的表达。方法:采用免疫组织化学SP法检测Dc R3蛋白在胆囊癌组织、胆囊管状腺瘤组织、胆囊腺肌瘤病组织及慢性胆囊炎组织中的表达,藉此评价其与多种临床特征之间的关系。结果:胆囊癌组织中Dc R3阳性表达率为68.4%(26/38),胆囊管状腺瘤、胆囊腺肌瘤病及慢性胆囊炎组织的Dc R3阳性表达率分别为10%(2/20)、18.6%(3/16)及5.6%(2/26)。Dc R3的表达水平均与胆囊癌的淋巴转移及TNM分期有关(均P<0.01)。结论:Dc R3在胆囊癌组织中具有较高的表达率,特别在有淋巴结转移及临床病理分期的癌组织中表达增高,Dc R3的过度表达在胆囊癌的发生、发展过程中起着重要作用。
Objective To explore the expression of Dc R3 protein in gallbladder carcinoma tissue.MethodsDc R3 protein was detected by immunohistochemical SP method in the gallbladder, gallbladder tubu-lar adenoma tissue, adenomyoma gallbladder diseases and chronic cholecystitis tissue of expression, trying tofind out the variety of the relationship between clinical features.ResultsThe positive rate of Dc R3 expres-sion in gallbladder cancer tissues was 68.4%（26/38）,the positive expression of Dc R3 in tubular adenoma of thegallbladder, gallbladder adenomyomatosis and chronic cholecystitis tissues were 10%（2/20）, 18.6%（3/16） and5.6%（2/26） correspondingly. The expression of Dc R3 was well associated with lymph node metastasis and TNMstage（ all P 0.05）.ConclusionThe expression of Dc R3 in gallbladder carcinoma shows a high rate, espe-cially in the increased expression of metastasis and clinical pathological stage of carcinoma of lymph node. Theexcessive expression of Dc R3 in the occurrence and development of gallbladder plays an important role in theprocess.
出处
《中国中西医结合外科杂志》
CAS
2015年第1期3-6,共4页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
关键词
胆囊癌
诱捕受体3
免疫组织化学
Gallbladder carcinoma
decoy receptor 3
immunohistochemistry
