摘要
随着肿瘤分子生物学的飞速发展,分子靶向治疗已成为肿瘤治疗方法中最具前景的研究领域,分子靶点的研究也早已成为医学界关注的热点。人造血相关的PBX相互作用蛋白质(HPIP)是一种新型的支架蛋白。近年来根据相关文献报道,HPIP与肿瘤生的长、增殖和转移密切相关,有可能成为肿瘤治疗的新靶点。本文总结了HPIP在恶性肿瘤发展中的作用及其相关机制的研究进展。
With the rapid development of tumor molecular biology,molecular targeted therapy has become the most promising treatment of cancer and the study of molecular targets has been to be a hot topic for a long time. Remarkably,hematopoietic Pbx-interaction protein( HPIP),a microtubule-binding protein,is a novel scaffolding protein. To date,according to the relevant literature,HPIP is closely associated with tumor growth,proliferation and metastasis. HPIP may be a new target for cancer therapy in the future.We review a representative set of resent studies and summarizes the progress of mechanisms and significance of HPIP in the development of malignant tumors.
出处
《临床肿瘤学杂志》
CAS
2015年第1期83-86,共4页
Chinese Clinical Oncology
基金
国家自然科学基金青年基金资助项目(81302067)