摘要
目的探讨首发未用药精神分裂症患者认知功能、生活技能状况及其与临床特征的关系。方法纳入首发精神分裂症住院患者145例和65名正常对照,采用精神分裂症认知功能成套测验中文版（MATRICS consensus cognitive battery,MCCB）、Stroop色词测验等评估两组认知功能,加州大学圣地亚哥分校基于任务的生活技能测验（University of California,San Diego performance-based skill assessment,UPSA）评估生活技能,阳性和阴性症状量表（positive and negative syndrome scale,PANSS）评估患者精神症状。结果患者组的MCCB总分、10项分测验、数字广度测验、情绪识别测验、Stroop色词测验得分均低于对照（均P〈0.05）;患者组的UPSA财务技能分、交流技能分及UPSA总分均低于对照组（均P〈0.05）。偏执型精神分裂症患者的语言记忆、视觉记忆评分、Stroop色词测验、UPSA交流技能分、UPSA总分高于非偏执型患者（均P〈0.05）。Logistic回归分析显示MCCB的影响因素为受教育年限（OR=1.29,95%CI：1.13~1.47）及PANSS总分（OR=0.95,95%CI：0.92~0.97）。结论首发未用药精神分裂症认知功能、生活技能明显受损,损害程度与精神病理症状有关联,偏执型患者的认知功能、生活技能好于非偏执型患者。
ObjectiveTo evaluate cognitive impairment and performance-based skills and to explore their relationships with clinical phenotypes in drug-na？ve first-episode patients with schizophrenia.MethodsOne hundred and forty-five inpatients and 65 healthy controls matched for age, gender and education were recruited. The MATRICS Consensus Cognitive Battery（MCCB）, Stroop, digit span test, emotional recognition test, University of California, San Diego,Performance-based Skill Assessment（UPSA） and Positive Negative Syndrome Scale scale（PANSS） were used to evaluate cognitive function, life skill and symptoms, respectively.ResultsCompared with the controls, total score of MCCB and scores of 10 subscales, scores of digit span, emotional recognition and Stroop were significantly lower in patients（all P0.05）. The UPSA total score and scores of financial skill and communication skill were lower in patients than in controls（all P0.05）. Verbal memory, visual memory, Stroop, communication skill scores and total UPSA standard score were significantly higher in patients with paranoid subtype of schizophrenia than in patients with non-paranoid subtype of schizo-phrenia（all P0.05）. The score of MCCB associated with education years（OR=1.29, 95%CI ： 1.13~1.47） and PANSS（OR=0.95, 95%CI ： 0.92~0.97）.ConclusionsFirst-episode, drug-naive patients with schizophrenia have markedly cognitive and performance-based skills deficits, which are associated with clinical symptoms. These deficits are differences between paranoid subtype and non-paranoid subtype of schizophrenia.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2015年第1期26-31,共6页
Chinese Journal of Nervous and Mental Diseases
基金
美国国立精神卫生研究所(NIMH)资助项目(编号:H-22473)
关键词
首发精神分裂症
认知功能
生活技能
精神病理
心理测量
First-episode schizophrenia patients Cognition Psychopathology Living skill Psychometrics
