摘要
目的探究异位妊娠患者应用甲氨蝶呤联合米非司酮治疗的临床效果和安全性。方法 随机选取本院2010年-2012年收治异位妊娠患者i00例并将其分为对照组与观察组，每组各有患者50例。对照组患者单纯接受甲氨蝶呤治疗，观察组患者在对照组治疗基础上联合米非司酮，对比2组患者临床疗效、血0-HCG指数恢复正常所需时间、住院时间以及不良反应等各项临床指标。结果观察组患者临床治疗有效率为96．0％，相对于对照组患者82．0％有显著优越性，对比存在统计学意义（P〈0．05）；观察组患者血8-HcG指数恢复正常所需时间、住院时间相对于对照组患者有显著优越性，对比无统计学意义（P〈0．05）观察组不良反应事件发生概率为10．0％，相对于时照组14．0％无统计学意义（P〉0．05）。结论对异位妊娠患者应用甲氨蝶呤联合米非司酮进行治疗能够取得令人满足的临床效果，且不会发生严重不良反应，具有安全高效的优点，值得临床推广。
Objective to explore the patients with ectopic pregnancy using methotrexate combined treatment the clinical effect and safety of mifepristone. Methods randomly selected from our hospital in 2010-2012 admitted 100 patients with ectopie pregnancy and divided into control group and observation group, 50 cases in each group with patients. Control group patients treated with methotrexate alone, the observation group of patients in the control group based on joint mifepristone treatment, compared two groups patients clinical curative effect and blood beta HCG index returned to norms time, length of hospital stay, and adverse reactions such as the clinical indicators. Results the observation group of patients with the clinical effective rate was 96.0%, 82.0% compared with the control group patients has significant advantages, compared to there is statistical significance （P〈0. 05） Observation group of patients with blood time needed for beta HCG index returned to normal, length of hospital stay compared with the control group patients has significant advantages, compared with no statistical significance （P〈0.05） Observation group adverse event probability is 10. 0%, compared with the control group 14.0% no statistical significance （P〉0.05）. Conclusion application of methotrexate in patients with ectopic pregnancy joint treated with mifepristone can obtain satisfying clinical effect, and no serious adverse reaction, possesses the advantages of safe and effective, worthy of clinical promotion.
出处
《中国地方病防治》
2014年第B08期358-359,共2页
Chinese Journal of Control of Endemic Diseases
