摘要
目的探讨食管癌放疗后局部复发再程放疗的治疗价值,并分析再程放疗及放疗联合化疗的疗效和不良反应。方法采用回顾性分析方法,对开封市中心医院2005-05-18-2010-05-21收治的41例食管癌患者,分为单纯再程放疗组20例及化疗联合再程放疗组21例,对其疗效、不良反应等进行比较。结果单纯再程放疗组有效率(RR)为45.00%(9/20),化疗联合再程放疗组为85.71%(18/21),差异有统计学意义,χ2=8.25,P=0.035。单纯再程放疗组1年生存率为45.00%(9/20),2年为25.00%(5/20),3年为10.00%(2/20);化疗联合再程放疗组1年生存率为52.38%(11/21),2年为28.57%(6/21),3年为14.29%(3/21);2组差异无统计学意义,χ2=0.05,P=0.975。单纯再程放疗组急性放射性食管炎发生率为75.00%(15/20),≥2级者为45.00%(9/20);化疗联合再程放疗组则分别为90.45%(19/21)和52.39%(11/21);2组差异无统计学意义,z=-0.877,P=0.380。单纯再程放疗组急性放射性肺炎发生率为20.00%(4/20),≥2级者为5.00%(1/20);化疗联合再程放疗组分别为23.81%(5/21)和9.52%(2/21);2组差异无统计学意义,z=-0.361,P=0.718。单纯再程放疗组骨髓抑制发生率为45.00%(9/20),≥2级者为5.00%(1/20);化疗联合再程放疗组分别为57.14%(12/21)和23.81%(5/21);2组差异无统计学意义,z=-1.228,P=0.220。结论食管癌放疗后局部复发再程放疗仍是有效治疗的手段,联合化疗是可行的,并能提高治疗效果,不良反应可耐受。
OBJECTIVE To research the value of re-course radiotherapy for local recurrence of esophageal cancer after radiotherapy, and analyze the curative effect and adverse reactions of re-course radiotherapy and radiotherapy combined with chemotherapy. METHODS The curative effect and adverse reactions of 20 patients with re-course radiotherapy and 21 patients with radiotherapy combined with chemotherapy were compared retrospectively. RESULTS The RR of recurrence in the re-course radiotherapy group was 45.00% （9/20）, while 85. 71%（18/21） in the radiotherapy combined with chemotherapy. There was statistically difference between the two groups （X2= 8. 25, P= 0. 035）. The 1-,2- and 3-year survival rates were 45. 00% （9/20）, 25. 00%（5/20） and 10. 00% （2/20） in the simple re-course radiotherapy gro up, while 52.38 % （ 11 / 21 ）, 28.57 % （6 / 21 ）, 14.29% （3 / 21 ） in the gro up of radiotherapy combined with chemotherapy. There was not statistically difference between the two groups （X2 = 0.05 ,P=0. 975）. Both treatment types were well-tolerated. As for adverse reactions, the acute radiation-induced esophagitis rate in the re-course radiotherapy group was 75.00% （15/20）,in which ≥Grade 2 was 45.00% （9/20）, and 90.45% （13/20） in the group of radiotherapy combined with chemotherapy, in which ≥ Grade 2 was 52. 39 % （ 11/21 ）. There was not statistically difference between the two groups （z=-0. 877, P= 0. 380）. In addition, the acute radiation-induced pneumonitis rate was 20.00 % （4/20）, in which ≥Grade 2 was 5.00% （1/20）,and 23.81% （5/21）, in which ≥Grade 2 was 45.00% （9/20）. There was not statistically difference between the two groups （z = - 0.361, P = 0.718）. Moreover, the myelosuppression rate was 9.52 % （2/21 ）, in which ≥Grade 2 was 5.00%（1/20） ,and 57.14%（12/21） ,in which ≥Grade 2 was 23.81%（5/20）. There was not statistically difference between the two groups （z =- 1. 228, P = 0. 220）. CONCLUSIONS Re-course radiot
出处
《中华肿瘤防治杂志》
CAS
北大核心
2015年第4期277-280,共4页
Chinese Journal of Cancer Prevention and Treatment
关键词
食管癌
再程放疗
疗效
不良反应
esophageal cancer re-course radiotherapy curative effect toxicity
