摘要
细胞穿透肽的细胞膜穿透作用借助于一种非选择性和受体非依赖性的方式。该特点使得细胞穿透肽介导的细胞摄取过程适用于较广泛的细胞类型,而这种普遍性对于癌症治疗和诊断领域的应用无疑是重大障碍。因此,将体循环给药的细胞穿透肽惰化形式在肿瘤等病变区域选择性地转变为活化态成为研究热点。本文重点关注引入酶敏感机制的可激活细胞穿膜肽及其靶向递送系统,对此类传递载体的研究概况进行综述。
Cell-penetrating peptides（CPPs） offer a non-selective and receptor-independent mode to promote cellular uptake. Although the non-specificity of CPP-mediated internalization allows this approach applicable to a wide range of tumor types potentially, their universality is a significant obstacle to their clinical utility for targeted delivery of cancer therapeutics and imaging agents. Accordingly, many reports have focused on selective switching of systemically delivered inert CPPs into their active form in lesions（tumor）. In this review, our attention is mainly confined to such an enzyme-sensitive domain incorporated delivery system with activatable CPPs（ACPPs）, which have displayed the exciting strength in balancing the CPPs＇ pros and cons, and potential in the treatment and diagnosis of some diseases.
出处
《药学学报》
CAS
CSCD
北大核心
2015年第2期141-147,共7页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(81302725
81273454)
国家"重大新药创制"科技重大专项资助项目(2013ZX09402103)
关键词
细胞穿透肽
可激活细胞穿透肽
酶敏感
cell-penetrating peptide
activatable cell-penetrating peptide
enzyme-sensitive
