摘要
目的系统评价β3肾上腺素能受体(β3-AR)基因第190位点T/C多态性与中国人2型糖尿病(T2DM)的相关性。方法计算机检索Pub Med、EMbase、Cochrane图书馆数据库(2012年第8期)、维普数据库、中国生物医学文献数据库、万方数据库、中国知网数据库,收集国内外关于β3-AR基因第190位点T/C多态性与T2DM相关性的病例对照研究,检索时限均为1980年10月-2013年10月。由2位评价者根据纳入与排除标准独立筛选文献、提取资料并评价质量后,采用Rev Man 5.0和Stata 12.0软件进行Meta分析,采用Egger线性回归法分析发表偏倚。结果共纳入11个研究,包括T2DM患者1 602例及对照1 773例。Meta分析结果显示:对于中国人群,T2DM病例组比对照组TC基因型比例更高,差异有统计学意义[OR=1.19,95%CI(1.01,1.40),P=0.04];T2DM病例组比对照组CC+TC基因型比例更高,差异有统计学意义[OR=1.23,95%CI(1.05,1.45),P=0.01];T2DM病例组比对照组具有等位基因C的比例更高,差异有统计学意义[OR=1.24,95%CI(1.08,1.43),P=0.003]。结论中国人群β3-AR基因第190位点等位基因C与T2DM发病有关。受纳入研究数量及质量所限,上述结论尚待进一步研究加以验证。
Objective To systematically evaluate the correlation between type-2 diabetes mellitus （T2DM） and T/ C polymorphism in 190 locus of β3-adrenergic receptor （β3-AR） gene in Chinese population. Methods The following databases such as CNKI, VIP, CBM, PubMed, EMbase, the Cochrane Library （Issue 8, 2012） and WanFang Data were searched to collect case-control studies on the correlation between T2DM and T/C polymorphism in 190 locus of β3-AR gene. The retrieval time was from October 1980 to October 2013. Two reviewers independently screened the literature according to the inclusion and exclusion criteria, extracted the data and assessed the quality. Then the meta-analysis was conducted by using RevMan 5.0 and Stata 12.0 software, and the publication bias was analyzed by means of Egger＇s linear regression. Results A total of 11 studies involving 1 602 T2DM patients and 1 773 healthy volunteers were included. The results of meta-analyses showed that, for Chinese population, TC genotype in case group was more than that in control group [OR=1.19, 95%CI （1.01, 1.40）, P=0.04]. CC＋TC genotype in case group was more than that in control group [OR=1.23, 95%CI （1.05, 1.45）, P=0.01]. Allele C in case group was more than that in control group [OR=1.24, 95%CI （1.08, 1.43）, P=0.003]. Conclusions The allele C in 190 locus of β3-AR gene in Chinese population is significantly associated with T2DM. For the quantity and quality limitation of the included studies, this conclusion has to be further proved by more studies.
出处
《华西医学》
CAS
2015年第1期12-17,共6页
West China Medical Journal
关键词
Β3肾上腺素能受体基因
多态性
2型糖尿病
中国人群
系统评价
β3-adrenergic receptor gene
Polymorphism
Type-2 Diabetes Mellitus
Chinese population
Systematic review
