摘要
Let-7家族是最古老而保守的micro RNAs(mi RNAs)之一,由于它在许多肿瘤中表达下降或缺失,故被认为是肿瘤抑制因子。LIN28是一种高度保守的RNA结合蛋白,在多种恶性肿瘤中过度表达,通过抑制let-7而发挥致癌功能。目前认为,LIN28/let-7通路与恶性肿瘤发生发展密切相关,因此深入研究LIN28/let-7信号通路的调控机制将为恶性肿瘤的诊断和治疗提供新的策略。
The let-7 family, one of the most ancient and highly conserved microRNAs （miRNAs）, plays critical roles in tumor suppressing. However, during normal development, accumulation of let-7 can be prevented by LIN28, a highly conserved RNA-binding protein, suggesting that over-expression of LIN28 might promote ma- lignancy via repression of let-7. Emerging evidences suggest that LIN28/let-7 signal pathway can not only partly reveal the mechanism of tumorigenesis, but also guide the treatment of cancers.
出处
《中国细胞生物学学报》
CAS
CSCD
2015年第1期143-147,共5页
Chinese Journal of Cell Biology
基金
国家自然科学基金(批准号:81472333)资助的课题~~
