摘要
目的观察内界膜剥除联合玻璃体腔内注射曲安奈德（TA）治疗特发性黄斑前膜（IMEM）合并黄斑水肿的疗效。方法临床病例对比研究。对2010年5月至2013年3月在安阳市眼科医院就诊的40例（40只眼）特发性黄斑前膜患者按是否剥除内界膜分成两组：18例将黄斑前膜剥除后再剥除内界膜，然后玻璃体腔内注射4mg曲安奈德作为联合组；另外。22例仅行黄斑前膜剥除作为对照组。观察两组患者术前、术后1、3个月、末次随访时最佳矫正视力（BCVA）和黄斑中心凹视网膜厚度（CMT）。结果术后1、3个月、末次随访时，两组BCVA逐渐提高，与术前比较差异有统计学意义（均P〈0．05）。术后1、3个月、末次随访，两组CMT与术前比较，CMT值逐渐减少，差异有统计学意义（均P〈0．05）。术前两组BCVA和CMT比较差异均无统计学意义（P〉O．05），术后1、3个月、末次随访时联合组视力好于对照组且差异有统计学意义（P=0．006、0．008、0．015，均P〈0．05）；术后1、3个月、末次随访时联合组CMT值低于对照组且差异有统计学意义（P=0．000、0．000、0．012，均P〈0．05）。结论黄斑前膜和内界膜剥除联合玻璃体腔内注射曲安奈德能更有效地减轻黄斑水肿，提高视力。
Objective To observe the effect to macular edema induced by idiopathic macular epiretinal membrane by means of removing macular epiretinal membrane and inner limiting mem- brane adding to injecting TA into vitreous space. Methods There were 40 eyes in this study that were separated into two groups, one group （18 eyes） treated by removing rnacular epiretinal mem- brane and inner limiting membrane adding to injecting TA into vitreous space, another group （22 eyes） treated only by removing macular epiretinal membrane. The change of the vision and the thickness of macular before and after operation （1 month, 3 months and last follow-up visit） were ob- served. Results The vision promoted gradually in 1 month, 3 months and last follow-up visit after operation, the difference was significant, P 〈0.05. The thickness of macular decreased obviously, the difference was significant, P 〈0.05. There was significant difference between two groups of BCVA in 1 month, 3months and last follow-up visit （P =0.006, 0.008, 0.015）, as same as CMT in 1 month, 3 months and last follow-up visit （P =0.000, 0.000, 0.012）. Conclusions Removing macular epiretinal membrane and inner limiting membrane adding to injecting TA into vitreous space can promote the function of macular and increase the vision.
出处
《中国实用眼科杂志》
2015年第1期84-87,共4页
Chinese Journal of Practical Ophthalmology
关键词
特发性黄斑前膜
黄斑水肿
玻璃体腔内注射
曲安奈德
Idiopathic macular epiretinal membrane
Macular edema
Vitreous injection
Triam- cinolone acetonide
