摘要
目的研究A型肉毒毒素(BTX-A)治疗偏头痛的机理。方法建立偏头痛大鼠模型,分别应用BTX-A皮下注射(BTX-A组)及生理盐水注射(生理盐水组)治疗,并设立健康对照(对照组)。采用放射免疫法测定各组降钙素基因相关肽(CGRP)和P物质(SP)含量。结果生理盐水组CGRP、SP含量高于对照组(P均<0.05),BTX-A组低于生理盐水组(P均<0.05)。结论 BTX-A抑制三叉神经感觉通路CGRP及SP释放可能是其治疗偏头痛大鼠的机制之一。
Objective To explore the mechanism of botulinum toxin type A（ BTX-A） in treatment of migraine of rats.Methods The migraine rat models were established and then were respectively given subcutaneous injection of BTXA（ BTX-A group） and normal saline（ NS group）; additionally,the healthy rats were selected as the control group.The contents of calcitonin gene related peptide（ CGRP） and substance P（ SP） were detected by radioimmunoassay.Results The contents of CGRP and SP in the NS group were higher than those of the control group,but they decreased significantly in the BTX-A group as compared with those of the NS group（ all P〈 0.05）.Conclusion BTX-A inhibits SP and CGRP releasing from trigeminal sensory pathways,which may be one of the mechanisms of BTX-A in treatment of migraine.
出处
《山东医药》
CAS
2014年第9期34-35,共2页
Shandong Medical Journal
基金
川北医学院科研发展重点培育项目(CBY13-A-ZP21)
