摘要
目前非酒精性脂肪性肝病(NAFLD)在全球的高发病率不容忽视,其疾病谱涵盖广、早期不易被发现的特点对合适的诊断方法提出了迫切的需求。在临床上超声诊断NAFLD因其花费低、辐射小、依从性好等特点而被广泛应用。在动物模型的研究中,近年来也有多种超声检测方法可用于无创检测动物NAFLD的病变程度。本文从定性检测和半定量检测两个方面概述了不同超声检测方法检测动物NAFLD的原理,探讨了不同检测方法在NAFLD各阶段动物模型中的应用,以期在不同阶段NAFLD动物模型中选择最合适的超声诊断方法,从而提高动物模型病变程度和药物治疗效果评价的便捷性、准确性及可靠性。
The high prevalence of non-alcoholic fatty liver disease（NAFLD） all around the world is a great threat which cannot be ignored. It shows urgent need for the appropriate methods of NAFLD diagnosis because of the broad spectrum of hepatic derangements and the undetectable characteristic in the early stage of this disease. Ultrasonic diagnosis for NAFLD is widely used in clinic clue to its advantages such as low cost,weak radiation and good compliance for patients. For the studies in animal models,the pathological progression of NAFLD can be evaluated by a variety of noninvasive ultrasonic methods recently. To improve the convenience,accuracy and reliability of the estimation of NAFLD progression in animal models,the applications and the principles of the ultrasonic technics are introduced. Diverse qualitative and semi-quantitative methods for animal NAFLD detection are reviewed.
出处
《国际药学研究杂志》
CAS
CSCD
北大核心
2015年第1期20-24,4,共5页
Journal of International Pharmaceutical Research
基金
国家"重大新药创制"科技重大专项资助项目(2012ZX09103-101-063
2012ZX09301-002-004)
内蒙古自治区自然科学基金资助项目(2013MS1115)
关键词
实验性非酒精性脂肪性肝病
超声诊断
定性检测
半定量检测
experimental non-alcoholic fatty liver disease
ultrasonic diagnosis
qualitative determination
semi-quantitative determination
