摘要
目的：研究葛根四组药对生津止渴黄酮类药效组分的含量变化规律,探讨配伍、药效组分与饮片性味功能的相关性,为建立与临床疗效相对应的质量标准提供科学依据。方法：采用HPLC法梯度洗脱测定葛根生津止渴功效的四组药对中黄酮类药效组分3＇-羟基葛根素-葛根素-大豆苷-大豆苷元。结果：葛根-天花粉,葛根-黄芪,葛根-知母,葛根-玄参药对中葛根的黄酮类药效组分含量比例依次为2.05∶4.27∶1.12∶1,2.43∶5.15∶1.15∶1,2.08∶4.53∶1.00∶1,1.50∶4.12∶1.01∶1。结论：葛根生津止渴的黄酮类药效组分3＇-羟基葛根素-葛根素-大豆苷-大豆苷元比例范围为1.50-2.43∶4.12-5.15∶1.01-1.15∶1,可作为其质量控制的指标。
Objective：To study the determination variation of flavonoids active components alignment in four groups of Radix Puerariae Lobatae compatibilities. To investigate the correlation among compatibility,active components alignment and tastes of herbs function. To provide the scientific basis for establishing quality standard corresponding to clinic curative effect. Methods：The flavonoids active components alignment 3＇-hydroxy puerarin-puerarin-daidzin-daidzein in four groups of Radix Puerariae Lobatae compatibilities which can stimulate saliva and reduce thirst were analyzed by HPLC with gradient elution. Results：The proportion of determination of flavonoids active components alignment in Radix Puerariae Lobatae-Radix Trichosanthisk,Radix Puerariae Lobatae-Radix Astragali,Radix Puerariae LobataeRhizoma Anemarrhenae,Radix Puerariae Lobatae-Radix Scrophulariae was 2.05∶4.27∶1.12∶1,2.43∶5.15∶1.15∶1,2.08∶4.53∶1.00∶1,1.50∶4.12∶1.01∶1 respectively. Conclusion：The variation range of the flavonoids active components alignment in Radix Puerariae Lobatae which can stimulate saliva and reduce thirst in which 3＇-hydroxy puerarin-puerarin-daidzin-daidzein was 1.50-2.43∶4.12-5.15∶1.01-1.15∶1,which can be scientific indicators for quality control.
出处
《辽宁中医药大学学报》
CAS
2015年第3期51-53,共3页
Journal of Liaoning University of Traditional Chinese Medicine
关键词
葛根
药对
生津止渴
药效组分
与临床疗效对应
Radix Puerariae Lobatae
drug pair
stimulating saliva and reducing thirst
active components alignment
correspondence with clinical efficacy
