摘要
目的:探讨艾塞那肽联合二甲双胍治疗口服降糖药控制不佳的超重或肥胖2型糖尿病(T2DM)患者的临床疗效。方法:选择口服降糖药后血糖控制不佳的超重或肥胖T2DM患者24例,予艾塞那肽联合二甲双胍治疗,比较治疗前后体重、腰围、血压、BMI、血脂、血糖控制及胰岛素分泌指数(HOMA-%B)、胰岛素抵抗指数(HOMA-IR)的变化。结果:治疗后患者体重、BMI、腰围、SBP、DBP、FBG、2h PBG、TC、TG、Hb A1c、HOMA-IR较治疗前均显著降低,而空腹C肽及HOMA-%B较治疗前升高,差异均有统计学意义(P<0.05);胃肠道反应为最常见的不良反应,且无严重低血糖反应。结论:艾塞那肽联合二甲双胍治疗口服降糖药控制不佳的超重或肥胖T2DM患者,可有效控血糖,降低体重,改善血脂代谢及β细胞功能和减轻胰岛素抵抗,且低血糖反应发生率低,是一种安全有效的理想治疗方案。
Objective：To investigate the efficacy of exenatide combined with metformin in patients of o-verweight or obesity with type 2 diabetes inadequately controlled in blood glucose .Method：24 patients of o-verweight or obesity with type 2 diabetes inadequately controlled in blood glucose were treated by exenatide combined with metformin ,the body weight , waistline,blood pressure ,lipids,blood glucose control and insu-lin secretion index （HOMA-%B）, insulin resistance index （HOMA-IR） changes were compared after treatment.Result：After treatment ,the body weight,Wt,BMI,SBP,DBP,TC,TG, FBG, 2h PBG, HbA1c, HOMA-IR were significantly lower , and the fasting C-peptide and HOMA-%B were increased , the differ-ence was statistically significant （ P〈0.05 ）;the most common adverse reactions was gastrointestinal tract , and there＆#39;s no severe hypoglycemic reaction .Conclusion： The treatment of exenatide combined with met-formin in patients of overweight or obesity with type 2 diabetes inadequately controlled in blood glucose can effectively control blood glucose , reduce body weight , improve lipid metabolism and β-cell function and re-duce the insulin resistance , and with low incidence of hypoglycemia ,it is a safe and effective method .
出处
《河北医学》
CAS
2015年第3期404-407,共4页
Hebei Medicine
基金
广东省深圳市盐田区科技计划项目
(编号:2013-1-1-6)
