摘要
目的探讨白细胞分类计数与冠状动脉慢血流的相关性。方法对161例经冠状动脉造影检查证实无明显狭窄患者进行研究，其中冠状动脉慢血流（Slow Coronary Flow，SCF）患者84例，正常血流（Normal Coronary Flow，NCF）患者77例。抽取术前空腹静脉血测定中性粒细胞计数、淋巴细胞计数、嗜酸性粒细胞计数、嗜碱性粒细胞及单核细胞计数，计算中性粒细胞与淋巴细胞比值（Neutrophil to Lymphocyte Ratio，NLR）。结果SCF组NLR、中性粒细胞及单核细胞计数均显著高于NCF组，分别为：2．31±0．88、1．96±0．71，P=0．007；（4．14±1．13）×10^9、（3．66±1．20）×10^9，P=0．011；（0．51±0．15）×10^9、（0．46±0．13）×10^9，P：0．017），而淋巴细胞、嗜酸性及嗜碱性粒细胞计数组间比较差异未见统计学意义分别为：（1．94±0．63）×10^9、（1．96±0．55）×10^9，P〉0．05；（0．17±0．12）×10^9、（0．15±0．13）×10^9，P〉0．05；（0．04±0．01）×10^9、（0．03±0．02）×10^9，P〉0．05。Logistic回归分析显示NLR（OR=3．448，95％CI：1．065—11．165，P=0．039）可能是SCF现象的独立危险因素，ROC曲线表明NLR（曲线下面积为0．618）对SCF现象的发生具有重要的预测价值（敏感性为53．6％，特异性为72．7％）。结论中性粒细胞、单核细胞可能参与了SCF现象的病理生理过程，增高的白细胞计数显示SCF可能是一种慢性炎症状态，NLR可能是发生SCF现象的独立危险因素，其可作为临床无创性预测SCF的指标。
Objective To investigate the correlation of white blood cell differential count with slow coronary flow （ SCF ）. Methods A total of 161 patients confirmed with no significant stenosis through coronary angiography were investigated. Among all the patients, there were 84 patients with SCF and 77 patients with normal coronary flow （NCF）. The preoperative fasting venous blood of them was tested to determine neutrophil count, lymphocyte count, eosinophil count, basophil and monocyte count, then to calculate the neutrophil to lymphocyte ratio（NLR）. Results Basal characteristics were similar between the two groups. The NLR, neutrophil and monocyte in SCF group was significantly higher in comparison with the NCF group （2. 31 ±0. 88,1.96 ±0. 71, P =0. 007） ;（4. 14 ±1.13） ×10^9 ,（3.66 ±1.20） ×10^9, P =0. 011 ; （0. 51 ±0. 15） ×10^9, （0.46 ±0. 13） ×10^9, P =0. 017, while eosinophil, basophil and lymphocyte had no difference （1.94±0.63） ×10^9, （1.96±0.55）×10^9,p 〉0.05; （0. 17 ±0. 12）×10^9,（0. 15 ±0. 13） ×10^9, P 〉0. 05 ; （0. 04 ±0. 01 ）×10^9 , （0. 03 ±0. 02） ×10^9, P 〉0. 05. Logistic regression analysis showed that NLR（OR =3. 448, 95% CI： 1. 065 - 11. 165, P =0. 039） may be the independent risk factor of SCF phenomenon. ROC curve indicated that NLR （area under curve： 0. 618, sensitivity： 53.6%, specificity： 72. 7% ）had important value on predicting SCF phenomenon. Conclusions Neutrophil and monocyte may be involved in the pathophysiologic process of SCF phenomenon, increased white blood cell count demon- strated SCF phenomenon is a chronic inflammatory state. NLR is the likely independent risk factor of SCF phenomenon, and it can be used as a non-invasive predictor for SCF phenomenon.
出处
《中国实用医刊》
2015年第5期38-40,共3页
Chinese Journal of Practical Medicine
