摘要
目的比较阿立哌唑、喹硫平、氯氮平治疗精神分裂症的疗效和安全性。方法本研究为疗程8周的开放、多中心的回顾性临床研究。观察期间为单一药物治疗,将249名患者分为3组阿立哌唑组79例（10-30 mg/d）,喹硫平89例（100-800 mg/d）,氯氮平81例（100-600 mg/d）可以适当合并苯二氮卓类改善睡眠。分别于治疗开始时,治疗第4周,治疗第8周由专业医生用阳性症状与阴性症状量表（PANSS）评定疗效;在开始前和第8周进行实验室检查和心电图测定;记录基线,第4周,第8周的不良事件。结果临床疗效以治疗8周PANSS减分率≥50%占所在组的比例来评定疗效,阿立哌唑组71.8%、喹硫平组71.6%、氯氮平组71.8%。三组间疗效差异无统计学意义（P〉0.05）。结论三种药物对精神分裂症的疗效相当,但氯氮平和喹硫平对心率和体重的影响较阿立哌唑大;阿立哌唑组锥体外系反应发生率高于其它两组。
Objective To compare the Aripiprazole,quetiapine and clozapine in the treatment of schizophrenia in the efficacy and safety. Methods The study of course of 8 weeks of open,multicenter retrospective clinical study. Observation period for a single drug treatment,249 patients were divided into 3 groups,to Aripiprazole group 79 cases （10 - 30 mg/d）,quetiapine flat in 89 cases （100 - 800 mg/d）, clozapine,81 cases （100 - 600 mg/d） can merge benzodiazepines appropriately improve sleep. Results The curative effects between the three groups have no statistical significance （P〉0.05）. Conclusion The curative effect of three kinds of drugs for schizophrenia, but chlorine nitrogen and quetiapine flat effect on heart rate and weight Aripiprazole thiazole; Aripiprazole groups extrapyramidal reaction rate is higher than other two groups.
出处
《中国卫生标准管理》
2015年第4期129-130,共2页
China Health Standard Management
