摘要
目的：探讨老年良性前列腺增生症（BPH）患者血清胱抑素 C（Cys C）的变化，及其与肾功能的相关性。方法：回顾性分析237例老年 BPH 患者的临床资料，按照国际前列腺症状评分（IPSS），分为轻度25例、中度67例、重度145例；纳入同期非前列腺增生患者110例作为正常对照组。检测各组血清 Cys C、血尿素氮（BUN）、肌酐（Scr）、空腹血糖（FBG）、血脂和前列腺特异性抗原（PSA）水平，计算前列腺体积（PV）。结果：与正常对照组比较，BPH 患者的 PV显著增大[（18.94±4.62）ml 比（40.09±12.72）ml]，最大尿流率（Qmax ）显著降低[（18.67±4.60）ml／s 比（9.93±3.54）ml／s]，血清 Cys C 水平显著升高[（1.03±0.23）mg／L 比（1.53±0.61）mg／L]，P 均＜0.01。亚组分析显示，在轻、中、重度 BPH 组血清 Cys C 水平[（1.32±0.45）mg／L，（1.42±0.32）mg／L，（1.61±0.64）mg／L]均显著高于正常对照组（P 均＜0.01）；且重度组显著高于轻、中度组（P ＜0.01或 P ＜0.05）。Pearson 相关分析显示，血清 Cys C与 BPH 患者的年龄、收缩压、舒张压、FBG、BUN、Scr、PV、IPSS 评分均呈显著正相关（r＝0.179～0.580，P ＜0.05或＜0.01），与 Qmax 呈显著负相关（r＝－0.243，P ＜0.05）。结论：血清 Cys C 水平在老年 BPH 患者显著升高，且与前列腺增生程度有关，与肾功能相关，可用于预测老年 BPH 患者的肾功能。
Objective：To explore the correlation between serum cystatin C （Cys C）content and renal function in aged patients with benign prostatic hyperplasia （BPH）.Methods：Clinical data of 237 aged BPH patients were retro-spectively analyzed.According to international prostate symptom score （IPSS）,they were divided into mild group （n=25）,moderate group （n=67）and severe group （n= 145）;another 110 patients without prostatic hyperplasia were enrolled as normal control group in the same period.Levels of serum Cys C,blood urea nitrogen （BUN）,ser-um creatinine （Scr）,fasting blood glucose （FBG）,blood lipids and prostate-specific antigen （PSA）were measured in all groups,and prostate volume （PV）was calculated.Results：Compared with normal control group,PV signifi-cantly rose [（18.94±4.62）ml vs.（40.09±12.72）ml],maximum urinary flow rate （Qmax）significantly reduced [（18.67±4.60）ml/s vs.（9.93±3.54）ml/s],and serum Cys C level significantly increased [（1.03±0.23）mg/L vs.（1.53±0.61）mg/L]in BPH group,P 〈0.01 all.Subgroup analysis indicated that serum Cys C levels in mild, moderate and severe group [（1.32±0.45）mg/L,（1.42±0.32）mg/L,（1.61 ±0.64）mg/L]were significantly higher than that of normal control group,P 〈0.01 all;and that of severe group was significantly higher than those of mild group and moderate group （P 〈0.01 or P 〈0.05）.Pearson correlation analysis indicated that serum Cys C level was positively correlated with of age,SBP,DBP,FBG,BUN,Scr,PV and IPSS （r=0.179~0.580,P 〈0.05 or P 〈0.01）,and inversely correlated with Qmax （r=-0.243,P 〈0.05）in BPH patients.Conclusion：Serum Cys C level significantly rise,and related with BPH degree,correlated with renal function in aged BPH patients,which can be used to predict renal function of these patients.
出处
《心血管康复医学杂志》
CAS
2015年第1期16-20,共5页
Chinese Journal of Cardiovascular Rehabilitation Medicine
