摘要
血卟啉衍生物(HPD)因其独特的自发荧先和光毒作用以及能选择性地潴留于癌细胞中,而被作为光敏药物应用于癌症的临床诊断和治疗,至今已发展成肿瘤光动力学治疗这一新领域。大量临床治疗的结果表明,HPD-光动力学疗法具有定位准确、对肿瘤杀伤力强、同时对周围组织损伤小的优点。 人们已知辐射、高热和某些化疗药物等的作用皆受细胞周期的影响。Christensen等研究了体外培养的NHIK 3025细胞在细胞周期不同时期对血卟啉光敏作用的敏感性差异,发现各时期细胞对光敏作用的敏感性差异很大。
Human osrvix Hela cells were synchronized, collected and seeded into Rose chambers for experiment. Cells at G1, S and G2 stages were then treated in the medium with hematoporphyrin (HPD) and irradiated by a laser mierobeam at 632.8nm. It was found that in case of the occurrence of primary and significant visible damage, cells at S stage showed the earliest, G2 stage the next, and G1 stage the latest. Variance analysis demonstrated that the variations are statistically significant.
出处
《中国激光》
EI
CAS
CSCD
北大核心
1991年第4期316-320,共5页
Chinese Journal of Lasers
关键词
激光
癌症
HELA细胞
杀伤力
photodynamie therapy, laser mieroirradiation, HPD, cell cycle, Hela
